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Adipogen/LC3 [ATG8E] vinyl sulfone (human) (rec.) (HA)/AG-40T-0288-C025/25 µg
![Adipogen/LC3 [ATG8E] vinyl sulfone (human) (rec.) (HA)/AG-40T-0288-C025/25 µg](https://www.ebiomall.cn/images/adipogen/adipogen_logo_bw_2.png){kind=logo}
Adipogen/LC3 [ATG8E] vinyl sulfone (human) (rec.) (HA)/AG-40T-0288-C025/25 µg
商品编号：
AG-40T-0288-C025
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Microtubule-associatedproteins1A/1Blightchain3A;Autophagy-relatedproteinLC3A;Autophagy-relatedubiquitin-likemodifierLC3A;Microtubule-associatedprotein1lightchain3α;Apg8;APG8a;Apg8p3;MLP3A;MAP1LC3A |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanLC3(AccessionNr.NP_115903)fusedtoaN-terminalHA-tagandtaggedtovinylsulfone. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHepespH6.5,100mMNaCl,10%glycerol. |
| OtherProductData | Use:Potent,irreversIBLeandspecificinhibitorofAgp8-specificisopeptidases(suchasApg4B).Apg4BactivitiesincludetheprocessingofApg8precursorproteinsandtheremovalofApg8proteinsthatareconjugatedtophosphatidylethanolamineduringautophagy.TheseprocessescanbeinhibitedbythisvinylsulfonederivativewhichreactswiththeApg4Bactivesitecysteine.TheHA-epitopeallowsforthesensitiveidentificationorpurificationofsuchdeconjugatingactivitiessinceitisspecificallyrecognizedbyanti-HAantibodiesand/oranti-HA-agarose.Adddirectlytoinvitroassayfromthestocksolution.Dependingonconditionsanddetectionmethod,typicalconcentrationstofullyinhibitApgdeconjugatingenzymesinvitroare1-5μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Microtubule-associatedProtein(MAP)LightChain3(LC3)Aisa121aminoacid(aa)proteinwithapredictedmolecularweightof14kDa.ItisamemberoftheLC3subfamilyofautophagy-related8(Atg8)proteins.TheLC3subfamilyalsoincludesLC3BandLC3C.LC3exhibits100%aasequenceidentitywithitsmouseandratorthologs,andisorthologoustotheyeastautophagy-relatedproteinAtg8.Atg8familymembersshowstructuralsimilaritywithubiquitin,butlackaasequencesimilarity.LC3wasoriginallydescribedaspartispartofacomplexthatincludesheavyandlightchainscomprisingtheMAP1familyofmicrotubuleregulatoryproteins.However,LC3hasgainedattentionforMAP1-independentfunctionsinautophagy.LC3utilizesaubiquitin-likeconjugationsystemthatincludesE1-,E2-,andE3-likeenzymestocovalentlyattachphosphatidylethanolamine(PE)toitsC-terminus,incorporatingitintothephagophoremembraneduringtheearlystagesofautophagasomeformation.RecruitmentofLC3tothephagophoremaypromotemembraneelongation.Itmayalsobeinvolvedincargorecruitmenttoautophagosomes.LC3isoftenusedasaMarkerofautophagy.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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