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Adipogen/Kynurenine Aminotransferase II (human) (rec.) (His)/AG-40T-0102-C050/50 µg
Adipogen/Kynurenine Aminotransferase II (human) (rec.) (His)/AG-40T-0102-C050/50 µg
商品编号：
AG-40T-0102-C050
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | hKAT II; KAT2; α-Aminoadipate Aminotransferase (Mitochondrial); AADAT; EC 2.6.1.7 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human full-length KAT II is fused at the N-terminus to a His-tag. |
| Crossreactivity | Human |
| Application | Can be used to test potential kynurenic acid synthesis inhibitors by performing either in vitro end point assays followed by HPLC-UV (Lit. 2) or continuous spectrophotometric analysis (Lit. 3). |
| MW | ~49.8kDa |
| Purity | ≥97% (SDS-PAGE) |
| Endotoxin Content | N/A |
| Concentration | 0.5mg/ml (Lot specific) |
| Formulation | Liquid. In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP). |
| Other Product Data | NCBI link NP_872603: AADAT (human) |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice |
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Kynurenine aminotransferases (KATs) are pyridoxal-5’-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays β-elimination activity.
Product References
- Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia; F. Rossi, et al.; J. Biol. Chem. 283, 3559 (2008)
- Biochemical and Structural Investigations on Kynurenine Aminotransferase II: An Example of Conformation-Driven Species-Specific Inhibition?; V. Casazza, et al.; Curr. Top. Med. Chem. 11, 148 (2011)
- Human kynurenine aminotransferase II - reactivity with substrates and inhibitors; E. Passera, et al.; FEBS J. 278, 1882 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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