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Adipogen/LAG-3 (human):Fc (human) (rec.)/AG-40B-0031-C050/50 µg
| ProductDetails | |
|---|---|
| Synonyms | LymphocyteActivationGene-3;FDCProtein;CD223 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | Thesequencecodingforthe4extracellularIg-likedomainsofhumanLAG-3(D1-D4)isfusedtotheFcportionofhumanIgG1. |
| Crossreactivity | Human Monkey Mouse |
| Specificity | Bindstohuman,mouseandmonkeyMHCclassII. |
| BIOLOGicalActivity | InhibitsbindingofMAbtoLAG-3(human)toLAG-3.Inducesmaturationofhumandendriticcells. |
| MW | ~80kDa(SDS-PAGE) |
| Purity | ≥99%(SDS-PAGE) |
| EndotoxinContent | <0.001eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.InPBScontaining5mMarginine. |
| OtherProductData | Application: FlowCytometry:DetectionofMHCclassIImoleculesincombinationwithfluorescentlylabeledantibodiestoIgG1.ProductcontainsarginineforoptimizedproteinstABIlity. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/Stability | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. Containsarginineforoptimizedproteinstability. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Lymphocyteactivationgene3(LAG-3;CD223)playsanimportantroleinnegativelyregulatingTcellproliferation,functionandhomeostasis.ItisrequiredformaximalnaturalandinducedregulatoryTcell(Treg)function.LAG-3iscloselyrelatedtotheTcellco-receptorCD4andbindstoMHCclassIImoleculesbutwithasignificantlyhigheraffinitythanCD4.
- CD4/majorhistocompatibilitycomplexclassIIinteractionanalyzedwithCD4-andlymphocyteactivationgene-3(LAG-3)-Igfusionproteins:B.Huard,etal.;Eur.J.Immunol.25,2718(1995)
- TcellmajorhistocompatibilitycomplexclassIImoleculesdown-regulateCD4+TcellcloneresponsesfollowingLAG-3binding:B.Huard,etal.;Eur.J.Immunol.26,1180(1996)
- Maturationandactivationofdendriticcellsinducedbylymphocyteactivationgene-3(CD223):S.Andreae,etal.;J.Immunol.168,3874(2002)
- LAG-3(CD223)reducesmacrophageanddendriticcelldifferentiationfrommonocyteprecursors:S.Buisson&F.Triebel;Immunology114,369(2005)
- Asolublelymphocyteactivationgene-3(sLAG-3)proteinasaprognosticfactorinhumanbreastcancerexpressingestrogenorprogesteronereceptors:F.Triebel,etal.;CancerLett.235,147(2006)
- Asolubleformoflymphocyteactivationgene-3(IMP321)inducesactivationofalargerangeofhumaneffectorcytotoxiccells:C.Brignone,etal.;J.Immunol.179,4202(2007)
