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Adipogen/Jagged-1 (human):Fc (human) (rec.)/AG-40A-0081-C050/50 µg
Adipogen/Jagged-1 (human):Fc (human) (rec.)/AG-40A-0081-C050/50 µg
商品编号：
AG-40A-0081-C050
品牌：
Adipogen Inc
市场价：
¥7000.00
美元价：
4200.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ProteinJagged-1;hJ1;CD339;JAG1 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | SignalpeptideandextracellulardomainofhumanJagged-1(HJ1;CD339)(aa1-1067)arefusedattheC-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | InhibitsADIpogenesisofmesenchymalstemcells(MSCs).InducesHes-1in3T3L-1cells. |
| MW | ~150kDa(SDS-PAGE) |
| Purity | ≥90%(SDS-PAGE) |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.0.2μm-filteredsolutioninPBS. |
| OtherProductData | UniprotlinkP78504:Jagged-1[Precursor] |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Jagged-1isaligandformultipleNotchreceptorsandinvolvedinthemediationofNotchsignaling.Itisinvolvedincell-fatedecisionsduringhematopoiesis.Isinvolvedinearlyandlatestagesofmammaliancardiovasculardevelopment.Inhibitsmyoblastdifferentiation.Enhancesfibroblastgrowthfactor-inducedangiogenesis(invitro).DefectsinJagged-1arethecauseofAlagillesyndrometype1(ALGS1)andtetralogyofFallot(TOF).
ProductReferences
- Jagged1heterozygosityinmiceresultsinacongenitalcholangiopathywhichisreversedbyconcomitantdeletionofonecopyofPoglut1(Rumi):S.M.Thakurdas,etal.;Hepatology63,550(2016)
- Singlefactorsalonecaninducemesenchymal-likemorphology,butnotpromotefullEMTinbreastcancercelllineswithdifferenthormonestatuses:M.K.Tveitaras,etal.;Exp.CellRes.359,257(2017)
- Notchligandsregulatethemusclestem-likestate exvivo butarenotsufficientforretainingregenerativecapacity:H.Sakai,etal.;PLoSONE12,e0177516(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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