脂肪原/瘙痒异构体2（人类）（推荐）/AG-40T-0284-C100/100µg
商品编号：
AG-40T-0284-C100
品牌：
Adipogen Inc
市场价：
¥8940.00
美元价：
5364.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | E3 Ubiquitin-protein Ligase Itchy Homolog; Itchy E3 Ubiquitin Protein Ligase; AIF4; AIP4; NAPP1; Atrophin-1-interacting Protein 4; NFE2-associated Polypeptide 1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human ITCH Isoform 2 (Accession Nr. Q96J02-2). |
| Crossreactivity | Human |
| Formulation | Liquid. In HEPES, NaCl, Glycerol and TCEP. |
| Other Product Data | Use: HECT domain ubiquitin ligase (E3) that functions downstream of a ubiquitin-activating (E1) enzyme and a ubiquitin-conjugating (E2) enzyme to conjugate ubiquitin to substrate proteins. Demonstrates strong autoubiquitination activity in vitro. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-0.5µM. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
The mammalian Itchy homolog, or ITCH, (also known as Atrophin-1-interacting protein 4 or AIP4) is a HECT domain class ubiquitin E3 ligase. ITCH/AIP4 ubiquitinates the phosphorylated form of dishevelled protein and promotes its degradation via the ubiquitin proteasome system, thereby inhibiting canonical Wnt signaling. The absence of ITCH/AIP4 has been shown to cause severe autoimmune disease in mice. Recent studies have identified multisystem autoimmune disease and morphologic and developmental abnormalities in human patients with ITCH/AIP4 deficiency, thus underscoring the importance of ITCH/AIP4 in many cellular processes. This ligase may catalyze K29-, K48-, and/or K63-linked polyubiquitin chain formation on a variety of reported targets.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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