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Adipogen/Isopeptidase T (human) (rec.)/AG-40T-0282-C025/25 µg
Adipogen/Isopeptidase T (human) (rec.)/AG-40T-0282-C025/25 µg
商品编号：
AG-40T-0282-C025
品牌：
Adipogen Inc
市场价：
¥3860.00
美元价：
2316.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinSpecificProtease5;USP5;IsoT;UbiquitinCarboxyl-terminalHydrolase5;DeubiquitinatingEnzyme5;UbiquitinThioesterase5 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanisopeptidaseT(AccessionNr.P45974). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,150mMNaCl,1mMDTT. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialenzymeconcentrationof10-100nM.15minutepre-incubationwith10mMDTTisrecommendedtoachievemaximumactivity. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
IsopeptidaseT/UbiquitinSpecificPeptidase5(USP5)isawidelyexpresseddeubiquitinatingenzymebelongingtothepeptidaseC19family.Itistheonlyknownmemberthatrequireszincbindingtobeactive.Ithasapredictedmolecularweightof95.8kDa.HumanIsopeptidaseT/USP5is858aminoacids(aa)inlengthandshares98%aasequenceidentitywiththemouseandratorthologs.IsopeptidaseT/USP5islargelyresponsIBLeforthedisassemblyofunanchoredpoly-ubiquitinchains.Itbindsmultipleubiquitinmoleculesinapoly-ubiquitinchainandcancleaveLys29-,Lys48-andLys63-linkedchains.Itcontainsfourputativeubiquitin-bindingdomains:anN-terminalzincfingerubiquitin-binding(ZnF-UBP)domain,aubiquitin-specificprocessingprotease(UBP)catalyticdomain,andtwoubiquitin-associateddomains(UBA1andUBA2).TheZnF-UBPdomain(aa163-291)selectivelyinteractswithanunmodifiedC-terminusofpoly-ubiquitinchainsandinducesaconformationalchangethatpreventsIsopeptidaseT/USP5fromdisassemblingpoly-ubiquitinuntilanotherdeubiquitinatingenzymehasreleasedthechainfromtheubiquitinatedprotein.TheUBPdomainbindsthesecondubiquitininpoly-ubiquitin,whilethesubsequentubiquitinsbindtheUBA2(aa722-762)andUBA1(aa654-695)domains.ThereareshortandlongformsofhumanIsopeptidaseT/USP5thatdifferbyaninsertionof23aainthelongform.SuppressionofIsopeptidaseT/USP5hasbeenshowntoincreasetheamountandtranscriptionalactivityofp53duetotheaccumulationofunanchoredpoly-ubiquitin.Conversely,anup-regulationofUSP5hasbeenassociatedwithfetaldownsyndrome.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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