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Adipogen/ISG15 E1 (human) (rec.) (GST)/AG-40T-0279-C050/50 µg
Adipogen/ISG15 E1 (human) (rec.) (GST)/AG-40T-0279-C050/50 µg
商品编号：
AG-40T-0279-C050
品牌：
Adipogen Inc
市场价：
¥8940.00
美元价：
5364.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-likeModifierActivatingEnzyme7;UBE2;Ubiquitin-activatingEnzyme7;D8;UBA1B;UBA7;UBE1L |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf9cells |
| Sequence | HumanISG15E1(AccessionNr.P41226)fusedtoaN-terminalGST-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPESandNaCl. |
| OtherProductData | Use:MemberoftheISG15-activating(E1)enzymefamilythatisrequiredforthefirststepoftheenzymaticcascadethatsubsequentlyutilizesaISG15-conjugating(E2)enzymeandaISG15ligase(E3)toconjugateISG15tosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-200nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interferon-stimulatedGene15(ISG15)ActivatingEnzyme(E1),alsoknownasubiquitin-activatingenzyme1-like(UBE1L),UBA7,andUBE2,isa1012aminoacid(aa)memberoftheubiquitin-activatingenzymefamilywithapredictedmolecularweightof111kDa.ThemouseandratISG15E1/UBE1Lorthologsshare80%aasequenceidentitywiththehumanprotein.ISG15E1/UBE1LcatalyzestheactivationoftheC-terminalcarboxylgroupofthesmallubiquitin-likemodifierISG15.LikeotherE1enzymes,ISG15E1/UBE1LcontainsaconservedATP-bindingdomainandanactivesitecysteineresidue,Cys599inhumans.ItisexpressedinmultipletissuesinresponsetoIFN-αor-β,butthecovalentattachmentofISG15toproteinsubstrates(ISGylation)isnotrequiredforIFN-αor-βsignaling.Inaddition,ISG15E1/UBE1Lknockoutmiceappeartohavenormalembryonicdevelopmentandfertility.However,ithasbeensuggestedthatISG15E1/UBE1Lmayplayaroleinviralimmunityastheseknockoutmicedemonstrateincreasedsusceptibilitytoinfluenzainfection.ISG15E1/UBE1Lhasalsobeenshowntomodulateerythroiddifferentiationandmediateretinoid-induceddifferentiationofacutepromyelocyticleukemiacells.ISG15E1/UBEL1isdownregulatedinlungcancerandhasbeenshowntodownregulateCyclinDinlungcancercells.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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