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Adipogen/ISG15 (human) (rec.) (Biotin)/AG-40T-0274B-C050/50 µg
Adipogen/ISG15 (human) (rec.) (Biotin)/AG-40T-0274B-C050/50 µg
商品编号：
AG-40T-0274B-C050
品牌：
Adipogen Inc
市场价：
¥3080.00
美元价：
1848.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ISG15Ubiquitin-likeModifier;G1P2;IFI15;IP17;UCRP |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanISG15(AccessionNr.P05161)conjugatedtobiotin. |
| Crossreactivity | Human |
| Label/Conjugates | Biotin |
| Formulation | Liquid.In50mMHepespH7.5,100mMNaCl. |
| OtherProductData | Use:ModifiedwithbiotinviaprimaryaminecouplingresultinginmodificationoflysineresiduesaswellastheN-terminus.CanbeconjugatedtosubstrateproteinsviathesubsequentactionsofaISG15-activating(E1)enzyme,aISG15-conjugating(E2)enzyme,andaISG15ligase(E3).Biotin-ISG15isidealforthevisualizationorquantificationofthioesterformationwithavidin-linkedreagents.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof1-5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interferon-stimulatedGene15(ISG15),alsoknownasUCRP,isaubiquitin-likeproteinthatiscovalentlycoupledtotargetproteinsinaprocesstermedISGylation.Itisa165aminoacid(aa)polypeptidewithapredictedmolecularweightof18kDa.ISG15exhibits66%aasequenceidentitywithitsmouseortholog.Structurally,ISG15consistsoftwotandemubiquitin-likedomainsthatshareasimilar3-dimensionalstructurewithubiquitinandotherubiquitin-likemodifiersincludingNEDD8andSUMO1.ModificationoftargetsbyISG15occursinastepwiseenzymaticprocesssimilartothatofubiquitin.EnzymesregulatingISGylationincludetheactivating(E1)enzymeUBE1L,theconjugating(E2)enzymeUbcH8,andligases(E3)suchasTRIM25andHERC5.RemovalofISG15iscatalyzedbythedeconjugatingenzymeUBP43/USP18.Functionally,ISG15hasputativerolesintheimmuneresponseandtumOrigenesis.ThisisreflectedbyintracellularISG15targetsthatincludeCyclinD1,tumorsuppressorp63,IRF3andarangeofviralproteins.Itisinducedbytype1interferonsandmicrobialinfectionandknockoutmiceexhibitanincreasedsensitivitytoinfectionbysomeviruses.ISG15canalsobesecretedbycellsoftheimmunesystemandmayactinacytokine-likemanner.Forinstance,itisproducedbyhumangranulocytesinresponsetomycobacteriumexposureandnaturalkillercellsandTcellsrespondtoextracellularISG15withIFN-γproduction.Furthersupportingaroleinimmunefunction,ISG15mutationsareassociatedwithMSMD,aninheriteddisordercharacterizedbyincreasedsusceptibilitytomycobacterialinfection.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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