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Adipogen/ISG15 (human) (rec.) (Agarose)/AG-40T-0275-R500/500 µl
Adipogen/ISG15 (human) (rec.) (Agarose)/AG-40T-0275-R500/500 µl
商品编号：
AG-40T-0275-R500
品牌：
Adipogen Inc
市场价：
¥5160.00
美元价：
3096.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ISG15Ubiquitin-likeModifier;G1P2;IFI15;IP17;UCRP |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanISG15(AccessionNr.P05161)coupledtoagarose. |
| Crossreactivity | Human |
| Label/Conjugates | Agarose |
| Formulation | Liquid.In50mMHEPES,250mMNaCland0.09%(w/v)SodiumAzide,pH7.5. |
| OtherProductData | Use:CovalentlycoupledtoagarosebeadsviaprimaryaminesallowingforafullyfunctionalC-terminus.IdealfortheenrichmentofknownISG15-interactingproteinsaswellasthediscoveryofnovelISG15-interactingproteins.Werecommendequilibratingtheresinbywashingwith5-10mlofyourdesiredaqueousbuffer. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Donotfreeze. |
| Use/StABIlity | Stableforatleast3monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interferon-stimulatedGene15(ISG15),alsoknownasUCRP,isaubiquitin-likeproteinthatiscovalentlycoupledtotargetproteinsinaprocesstermedISGylation.Itisa165aminoacid(aa)polypeptidewithapredictedmolecularweightof18kDa.ISG15exhibits66%aasequenceidentitywithitsmouseortholog.Structurally,ISG15consistsoftwotandemubiquitin-likedomainsthatshareasimilar3-dimensionalstructurewithubiquitinandotherubiquitin-likemodifiersincludingNEDD8andSUMO1.ModificationoftargetsbyISG15occursinastepwiseenzymaticprocesssimilartothatofubiquitin.EnzymesregulatingISGylationincludetheactivating(E1)enzymeUBE1L,theconjugating(E2)enzymeUbcH8,andligases(E3)suchasTRIM25andHERC5.RemovalofISG15iscatalyzedbythedeconjugatingenzymeUBP43/USP18.Functionally,ISG15hasputativerolesintheimmuneresponseandtumOrigenesis.ThisisreflectedbyintracellularISG15targetsthatincludeCyclinD1,tumorsuppressorp63,IRF3andarangeofviralproteins.Itisinducedbytype1interferonsandmicrobialinfectionandknockoutmiceexhibitanincreasedsensitivitytoinfectionbysomeviruses.ISG15canalsobesecretedbycellsoftheimmunesystemandmayactinacytokine-likemanner.Forinstance,itisproducedbyhumangranulocytesinresponsetomycobacteriumexposureandnaturalkillercellsandTcellsrespondtoextracellularISG15withIFN-γproduction.Furthersupportingaroleinimmunefunction,ISG15mutationsareassociatedwithMSMD,aninheriteddisordercharacterizedbyincreasedsusceptibilitytomycobacterialinfection.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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