当前位置：
首页
>
产品中心 >
Other_recombinant_protein >
Adipogen/IL-36Ra (aa 3-156) (mouse) (rec.) (untagged)/AG-40B-0096-3010/3 x 10 µg
Adipogen/IL-36Ra (aa 3-156) (mouse) (rec.) (untagged)/AG-40B-0096-3010/3 x 10 µg
商品编号：
AG-40B-0096-3010
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Interleukin-36 Receptor Antagonist Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1δ; Interleukin-1δ; Interleukin-1 Homolog 3; Interleukin-1-like Protein 1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Mouse IL36Ra (aa Val3-Asp156) is untagged. |
| Crossreactivity | Mouse |
| Application | Inhibition of biological activity of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). |
| Biological Activity | Inhibits the IL-6 induced expression of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9) in BMDCs. 1μg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists. |
| MW | ~17kDa |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.05eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
Uni-Prot link Q9QYY1: Interleukin-36 receptor antagonist protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
