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Adipogen/IL-35 (mouse):Fc (human) (rec.)/CHI-MF-11135-C005/5 µg
Adipogen/IL-35 (mouse):Fc (human) (rec.)/CHI-MF-11135-C005/5 µg
商品编号：
CHI-MF-11135-C005
品牌：
Adipogen Inc
市场价：
¥4600.00
美元价：
2760.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-35 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | AsolubledimericfusionproteinconsistingoftheextracellulardomainofmouseIL12asubunit(aa23-215)isfusedtotheFcregionofhumanIgG1,andthemouseEbi3subunit(aa23-228)linkedtoIL12abydisulfidebonds. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | BioactivitywasmeasuredinacellproliferationassayofConAactivatedmousesplenocytes. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_056581.1:Ebi3subunit(mouse) NCBIreferenceNP_032377.1:IL-12asubunit(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-35(IL-35)isanovelIL-12familycytokineproducedbyregulatoryTcells(Treg)butnotbyrestingoractivatedeffectorTcells(Teff).IL-35isaheterodimericproteincomposedofEBI3(Epstein-Barr-Virus-inducedgene3)andIL-12a(p35).EBI3isadownstreamtargetofFoxp3,atranscriptionfactorrequiredforTreg-celldevelopmentandfunction,andthusTreg-cellrestrictionofIL35occurs.RegulatoryTcellsareessentialformaintainingselftoleranceandpreventingautoimmunity,andIL-35isidentifiedasamoleculethatmediatestheimmunesuppressionfunctionofTreg-cell.Asaninhibitorycytokine,IL-35inducesproliferationofTreg-cellpopulationsbutsuppressesTh17celldevelopment.StudiesinmiceshowtheabsenceofeitherIL-35chainfromTreg-cellreducesthecells"abilitytosuppressinflammationusinganexperimentalmodelforinflammatoryboweldisease.IL-35issuggestedasapotentialtargetofimmunotherapy.Recently,insufficientIL-35levelswereshowntoplayapivotalroleinthedevelopmentoftype1diabetes(T1D)andautoimmunediseases.
ProductReferences
- Interleukin-35admiNISTrationcounteractsestablishedmurinetype1diabetes-possIBLeinvolvementofregulatoryTcells:K.Singh,etal.;Sci.Rep.5,ID12633(2015)
- CytokinemodulationbyIL-35inmicewithallergicrhinitis:M.Yokota,etal.;Am.J.Rhinol.Allergy29,251(2015)
- Remissionofsystemiclupuserythematosusdiseaseactivitywithregulatorycytokineinterleukin(IL)-35inMurphyRothsLarge(MRL)/lprmice:Z.Cai,etal.;Clin.Exp.Immunol.181,253(2015)
- IntranasaladministrationofIL-35inhibitsallergicresponsesandsymptomsinmicewithallergicrhinitis:M.Suzuki,etal.;Allergol.Int.(Epubaheadofprint)(2016)
- IL-35suppresseslipopolysaccharide-inducedairwayeosinophiliainEBI3-deficientmice:K.Kanai,etal.;J.Immunol.198,119(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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