脂肪原/IL-33（抗氧化）（人类）（记录）（未标记）/AG-40B-0160-C010/10µg
商品编号：
AG-40B-0160-C010
品牌：
Adipogen Inc
市场价：
¥5000.00
美元价：
3000.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | IL-33(human)(C208S/C232SMutant);Interleukin-33(human)(C208S/C232SMutant);IL-1F11;NF-HEV |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanIL-33(aa112-270)isuntagged.AminoacidsC208andC232havebeenmutatedtoserinetoprotectIL-33fromoxidation. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseST2. |
| BIOLOGicalActivity | ActivateshumanandmouseST2-dependentNF-κBpathway. |
| MW | ~17kDa |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | Afterreconstitution: for10µgsize:0.1mg/ml for100µgsize:1mg/ml |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkQ2YEJ5:Interleukin-33(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Interleukin-33(IL-33;HF-NEV;IL-1F11),amemberoftheIL-1familyofcytokines,isexpressedbymanycelltypesfollowingpro-inflammatorystimulationandisthoughttobereleaseduponcelllysis.IL-33bindstoandsignalsthroughST2(IL-1R1)anditsstimulationrecruitsMYD88,IRAK,IRAK4andTRAF6,followedbyphosphorylationofERK1(MAPK3)/ERK2(MAPK1),p38(MAPK14)andJNK.TheabilityofIL-33totargetnumerousimmunecelltypes,likeTh2-likecells,mastcellsandB1cells,andtoinducecytokineandchemokineproductionunderlinesitspotentialininfluencingtheoutcomeofawiderangeofdiseases,suchasarthritis,asthma,atopicallergy&anaphylaxis,cardiovasculardisease/atherosclerosis,nervoussystemdiseasesandsepsis.IL-33facilitatesTregexpansioninvitroandinvivo.Recently,IL-33hasbeeninvolvedinADIpocytedifferentiation.ThebiologicalactivityofIL-33atitsreceptorST2israpidlyterminatedintheextracellularenvironmentbyitsoxidation(formationoftwodisulfidebridges),resultinginanextensiveconformationalchangethatdisruptstheST2bindingsite.MutationsataminoacidsC208S/C232SprotectIL-33fromoxidationandincreaseitsactivity.
ProductReferences
- OxidationofthealarminIL-33regulatesST2-dependentinflammation:E.S.Cohen,etal.;Nat.Commun.6,ID8327(2015)
- Tumour-derivedPGD2andNKp30-B7H6engagementdrivesanimmunosuppressiveILC2-MDSCaxis:S.Trabanelli,etal.;Nat.Commun.8,593(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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