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Adipogen/IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-12002-5010/5 x 10 µg
Adipogen/IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-12002-5010/5 x 10 µg
商品编号：
CHI-MF-12002-5010
品牌：
Adipogen Inc
市场价：
¥12600.00
美元价：
7560.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-2;Aldesleukin |
| ProductType | Protein |
| Properties | |
| Source/Host | NS1cells |
| Sequence | TheextracellulardomainofmouseIL-2(aa21-169)isfusedtotheN-terminusoftheFcregionofamutantmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | SpecificActivity:1-1.5x106Units/mg,measuredusingCTLLindicatorcells. ShowsthebiologicalfunctionoftheIL-2moietyandexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain.Blocksdiabetogenicautoimmunityinnonobesediabeticmice. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceNP_032392.1:IL-2(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-2(IL-2)isa133aminoacidglycoproteinwithoneintramoleculardisulfidebondandvariableglycosylation.ItissecretedbyactivatedTcellsandinducesproliferationandmaturationofactivatedTcells,naturalkillercells,andlymphokineactivatedkillercells.IL-2alsostimulatesproliferationofantibody-producingBcells,activatesneutrophils,andinducesmononuclearcellstosecreteIFN-γandTNF-αand-β.Moreover,studieshaveshownthatIL-2isrequiredforactivation-inducedapoptosis,animportanthemeostaticmechanismintheimmunesystem,whichisinvolvedinthemaintenanceofperipheraltolerancetoself-antigens.
ProductReferences
- AdmiNISTrationofnoncytolyticIL-10/Fcinmurinemodelsoflipopolysaccharide-inducedsepticshockandallogeneicislettransplantation:X.X.Zheng,etal.;J.Immunol.154,5590(1995)
- AugmentationandsuppressionofimmuneresponsestoanHIV-1DNAvaccinebyplasmidcytokine/Igadministration:D.H.Barouch,etal.;J.Immunol.161,1875(1998)
- IL-2receptor-targetedcytolyticIL-2/Fcfusionproteintreatmentblocksdiabetogenicautoimmunityinnonobesediabeticmice:X.X.Zheng,etal.;J.Immunol.163,4041(1999)
- EffectsofCyclosporineonTransplantTolerance:TheRoleofIL-2:X.X.Zheng,etal.;Am.J.Transplant.7,1907(2007)
- Single-cellquantificationofIL-2responsebyeffectorandregulatoryTcellsrevealscriticalplasticityinimmuneresponse:O.Feinerman,etal.;Mol.Sys.Biol.6,437(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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