Adipogen/IL-18 (human) (rec.)/CHI-HR-20618-C010/10 µg
商品编号：
CHI-HR-20618-C010
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-18;Interferon-γ-inducingFactor;IGIF;IL-1γ;IL1F4 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanIL-18(aa37-193). |
| Crossreactivity | Human |
| MW | ~18kDa |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | ReconstitutedinsterileH2Onotlessthan100μg/ml,whichcanthenbefurtherdilutedinotheraqueoussolutions. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutionin1XPBS. |
| OtherProductData | NCBIreferenceNP_001553.1:IL-18(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-18(IL-18)isacostimulatoryfactorforproductionofinterferon-γ(IFN-γ)inresponsetotoxicshockandsharesfunctionalsimilaritieswithIL-12.IL-18issynthesizedasaprecursor24kDamoleculewithoutasignalpeptideandmustbecleavedtoproduceanactivemolecule.IL-1convertingenzyme(ICE;Caspase-1)cleavespro-IL-18atasparticacidintheP1position,producingthemature,bioactivepeptidethatisreADIlyreleasedfromthecells.ItisreportedthatIL-18isproducedfromKupffercells,activatedmacrophages,keratinocytes,intestinalepithelialcells,osteoblasts,adrenalcortexcellsandmurinediencephalon.IFN-γisproducedbyactivatedTorNKcellsandplayscriticalrolesinthedefenseagainstmicrobiralpathogens.IFN-γactivatesmacrophagesandenhancesNKactivityandBcellmaturation,proliferationandIgsecretion.IFN-γalsoinducesexpressionofMHCclassIandIIantigensandinhibitsosteoclastactivation.IL-18actsonThelpertype-1(Th1)TcellsandincombinationwithIL-12stronglyinducesthemtoproduceIFN-γ.PleiotropiceffectsofIL-18havealsobeenreported,suchasenhancementproductionofIFN-γandGM-CSFinperipheralbloodmononuclearcells,productionofTh1cytokines,IL-2,GM-CSF,IFN-γinTcellsandenhancementofFasligandexpressionbyTh1cells.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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