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Adipogen/IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)/CHI-HF-21115MBI-1/1 Vial
Adipogen/IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)/CHI-HF-21115MBI-1/1 Vial
商品编号：
CHI-HF-21115MBI-1
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-15 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanIL-15(aa49-162)includingmutationsatQ149DandQ156DisfusedtotheN-terminusoftheFcregionofmouseIgG2a. |
| Crossreactivity | Human |
| Label/Conjugates | Biotin |
| BIOLOGicalActivity | ThismutantIL-15/FcfusionproteinspecificallybindstotheIL-15R,competitivelyinhibitsIL-15-triggeredcellproliferation,promotestransplanttolerance,doesnotactivatetheSTAT-signalingpathway,andexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Formulation | Lyophilized.InPBSand0.09%sodiumazide. |
| OtherProductData | NCBIreferenceNP_751914.1:IL-15(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-15(IL-15)hasabroadspectrumofbiologicalactivities.Itiscrucialforthedevelopment,proliferation,survivalanddifferentiationofmultiplecellsfrombothinnateandadaptiveimmunesystems.IL-15up-regulationhasacentralroleinthedevelopmentofseveralautoimmuneorchronicinflammatorydisorders.TargetingIL-15oritsreceptormayhaveavaluableimpactonthetreatmentofimmune-mediateddiseases.IL-15participatesinthedevelopmentofimportantimmuneantitumormechanisms.ItactivatesCD8(+)Tcells,naturalkiller(NK)cells,NKTcells,andcanpromotetheformationofantitumorantibodies.IL-15canalsoprotectTeffectorcellsfromtheactionofTregulatorycellsandreversetolerancetotumor-associatedantigens.Inpre-clinicalstudiesIL-15hasbeenfoundtodemonstratepotentiatedantitumoreffectsfollowingpre-associationwithIL-15Rα,orwhenusedincombinationwithchemotherapy,adoptivetherapy,monoclonalantibodies,andtumorvaccines.
Application:UsefulforimmunofluorescentstainingandflowcytometricanalysistoidentifyandenumerateIL-15Rαexpressingcellswithinmixedcellpopulations.
Application:UsefulforimmunofluorescentstainingandflowcytometricanalysistoidentifyandenumerateIL-15Rαexpressingcellswithinmixedcellpopulations.
ProductReferences
- TargetingtheIL-15receptorwithanantagoNISTIL-15mutant/Fcgamma2aproteinblocksdelayed-typehypersensitivity:Y.S.Kim,etal.;J.Immunol.160,5742(1998)
- AnantagonistIL-15/Fcproteinpreventscostimulationblockade-resistantrejection:S.Ferrari-Lacraz,etal.;J.Immunol.167,3478(2001)
- FavorablytippingthebalancebetweencytopathicandregulatoryTcellstocreatetransplantationtolerance:X.X.Zheng,etal.;Immunity19,503(2003)
- Limitingγcexpressiondifferentiallyaffectssignalingviatheinterleukin(IL)-7andIL-15receptors:C.M.Smyth,etal.;Blood110,91(2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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