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Adipogen/IL-15 (mutant) (human):Fc (human) (rec.)/CHI-HF-21015M-C050/50 µg
Adipogen/IL-15 (mutant) (human):Fc (human) (rec.)/CHI-HF-21015M-C050/50 µg
商品编号：
CHI-HF-21015M-C050
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-15 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanIL-15(aa49-162)includingmutationsatQ149DandQ156DisfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | ThismutantIL-15/FcfusionproteinspecificallybindstotheIL-15R,competitivelyinhibitsIL-15-triggeredcellproliferation,promotestransplanttolerance,doesnotactivatetheSTAT-signalingpathway,andexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitute50µgvialin50µlsterilewater. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_751914.1:IL-15(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-15(IL-15)hasabroadspectrumofbiologicalactivities.Itiscrucialforthedevelopment,proliferation,survivalanddifferentiationofmultiplecellsfrombothinnateandadaptiveimmunesystems.IL-15up-regulationhasacentralroleinthedevelopmentofseveralautoimmuneorchronicinflammatorydisorders.TargetingIL-15oritsreceptormayhaveavaluableimpactonthetreatmentofimmune-mediateddiseases.IL-15participatesinthedevelopmentofimportantimmuneantitumormechanisms.ItactivatesCD8(+)Tcells,naturalkiller(NK)cells,NKTcells,andcanpromotetheformationofantitumorantibodies.IL-15canalsoprotectTeffectorcellsfromtheactionofTregulatorycellsandreversetolerancetotumor-associatedantigens.Inpre-clinicalstudiesIL-15hasbeenfoundtodemonstratepotentiatedantitumoreffectsfollowingpre-associationwithIL-15Rα,orwhenusedincombinationwithchemotherapy,adoptivetherapy,monoclonalantibodies,andtumorvaccines.
ProductReferences
- ADualActionofRheumatoidArthritisSynovialFibroblastIL-15ExpressionontheEquilibriumbetweenCD4+CD25+RegulatoryTCellsandCD4+CD25-ResponderTCells:M.Benito-Miguel,etal.;J.Immunol.183,8268(2009)
- IL-2/α-IL-2complextreatmentcannotbesubstitutedfortheadoptivetransferofregulatoryTcellstopromotebonemarrowengraftment:B.Mahr,etal.;PLoSOne11,e0146245(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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