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Adipogen/IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-12010-C010/10 µg
Adipogen/IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-12010-C010/10 µg
商品编号：
CHI-MF-12010-C010
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-10;CytokineSythesisInhibitoryFactor;CSIF |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofmouseIL-10(aa1-178)isfusedtotheN-terminusoftheFcregionofamutantmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | ShowsthebiologicalfunctionoftheIL-10moietyandexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceAAI37845.1:IL-10(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Interleukin-10(IL-10)isacytokineproducedbyactivatedTh2cells,Bcells,keratinocytesandmonocytes/macrophages.InvitromurineandhumanIL-10inhibitscytokinesynthesisbyTh1cells,naturalkillercellsandmonocytes/macrophages.SeveralstudieshavesuggestedthepotentialapplicationofIL-10asananti-inflammatoryagentinthetreatmentofsepticshockandasanimmunosuppressiveagentincertainTcellmediatedautoimmunediseases.
ProductReferences
- AdmiNISTrationofnoncytolyticIL-10/Fcinmurinemodelsoflipopolysaccharide-inducedsepticshockandallogeneicislettransplantation:X.X.Zheng,etal.;J.Immunol.154,5590(1995)
- RecombinantIL-10andIL-10/Fctreatmentdown-regulateeggantigen-specificdelayedhypersensitivityreactionsandegggranulomaformationinschistosomiasis:P.O.Flores-Villanueva,etal.;J.Immunol.156,3315(1996)
- AnoncytolyticIL-10/Fcfusionproteinpreventsdiabetes,blocksautoimmunity,andpromotessuppressorphenomenainNODmice:X.X.Zheng,etal.;J.Immunol.158,4507(1997)
- IL-10/Fcinhibitsmacrophagefunctionandprolongspancreaticisletxenograftsurvival:X.Feng,etal.;Transplantation68,1775(1999)
- CriticalroleofKupffercell-derivedIL-10forhostdefenseinsepticperitonitis:K.Emmanuilidis,etal.;J.Immunol.167,3919(2001)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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