脂肪原/IL-1和α(人类）（记录）/CHI-HF-20001A-C050/50µg
商品编号：
CHI-HF-20001A-C050
品牌：
Adipogen Inc
市场价：
¥10800.00
美元价：
6480.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-1α;IL-1F1;IL-1A |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | HumanIL-1α(aa113-271). |
| Crossreactivity | Human |
| BIOLOGicalActivity | TheED50 asdeterminedbythedose-dependentstimulationofmurineD10Scellsis≤0.001ng/ml,correspondingtoaspecificactivityof≥1x109units/mg. |
| MW | ~19kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitute10µgvialwith100µlsterilewatertoaconcentrationof0.1mg/ml. Reconstitute50µgvialwith100µlsterilewatertoaconcentrationof0.5mg/ml. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_000566.3:IL-1α(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Themostprominentmembersoftheinterleukin-1(IL-1)superfamilyareIL-1αandIL-1β.Theylackasignalpeptideandaresecretedbyanunconventional,endoplasmicreticulum-Golgi-independentmechanism.IL-1αwasreportedtobemorewidelyandconstitutivelyexpressedandhasintracellularfunctions,butalsoactslocallyinamembrane-boundformbyactivatingIL-1R1.Additionally,passivereleaseofIL-1αuponcelldeathcantriggerasterileinflammatoryresponsetodyingcells.ThecleavageofIL-1αisnotmediatedbycaspase-1andisnotrequiredforbindingtoIL-1R1.RecentlyithasbeenobservedthatallactivatorsoftheinflammasomeNLRP3/NALP3inducethesimultaneoussecretionofIL-1αandIL-1β.AlthoughmostactivatorsfullyrelyontheinflammasomeforIL-1αsecretion,someinducetheprocessingandsecretionofIL-1αinaninflammasome-independentmanner.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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