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Adipogen/IKK-β (human) (rec.) (His)/AG-40T-0122-C100/100 µg
Adipogen/IKK-β (human) (rec.) (His)/AG-40T-0122-C100/100 µg
商品编号：
AG-40T-0122-C100
品牌：
Adipogen Inc
市场价：
¥7000.00
美元价：
4200.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | InhibitorofNuclearFactorκBKinaseSubunitβ;IKK-B;IKK2 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf9cells |
| Sequence | RecombinanthumanIKK-β(aa1-700)isfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human |
| MW | ~80kDa(SDS-PAGE) |
| Purity | ≥85%(SDS-PAGE) |
| Concentration | 1mg/ml |
| Formulation | Liquid.In20mMTRIS-HCl,pH7.5,containing100mMsodiumchlorideand50%glycerol. |
| OtherProductData | UniProtIDO14920:IKK-β(human) |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IKK-βisaserinekinasethatplaysanessentialroleintheNF-κBsignalingpathway,whichisactivatedbymultiplestimulisuchasinflammatorycytokines,bacterialorviralproducts,DNAdamagesorothercellularstresses.ItactsaspartofthecanonicalIKKcomplexintheconventionalpathwayofNF-κBactivation.ItphosphorylatesinhibitorsofNF-κBandthesemodificationsallowpolyubiquitinationoftheinhibitorsandsubsequentdegradationbytheproteasome.Subsequently,NF-κBistranslocatedintothenucleusandactivatesthetranscriptionofhundredsofgenesinvolvedinimmuneresponse,growthcontrol,orprotectionagainstapoptosis.IKK-βphosphorylatesseveralothercomponentsofthesignalingpathwayincludingNEMO/IKBKG,NF-κBsubunitsRELAandNFKB1,aswellasIKK-relatedkinasesTBK1andIKBKE.ItphosphorylatesalsoothersubstratesincludingNCOA3,BCL10andIRS1.Withinthenucleus,itactsasanadapterproteinforNFKBIAdegradationinUV-inducedNF-κBactivation.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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