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Adipogen/IDO1 (human) Enzyme+Inhibitor Set/AG-44B-0006-KI01/1 Set
| ProductDetails | |
|---|---|
| Synonyms | Indoleamine2,3-dioxygenase;INDO;IDO |
| ProductType | Set |
| Properties | |
| ApplicationSet | CompoundScreening |
| Crossreactivity | Human |
| KitContains | 1Set 1x50µgofIDO1(human)(rec.)(His)(highlyactive)(Prod.No.AG-40B-0161) 1x100µgofMMG-0358(Prod.No.AG-CR1-3630) DownloadouronlineAssayProcedure/Protocol. |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| Manual | No |
| AssayProcedure |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IDO1isaheme-containingenzymethatcatalyzesthefirstandrate-limitingstepinthemainpathwayofhumantryptophancatabolism,thekynureninepathway,causingdepletionoftryptophanwhichcanleadtohaltedgrowthofmicrobesaswellasTcells.IDO1isanimmunecheckpointprotein,thatplaysaroleinavarietyofpathophysiologicalprocessessuchasantimicrobialandantitumordefense,neuropathology,immunoregulationandantioxidantactivity.
TheIDO1(human)Enzyme+InhibitorSetcontainstheactiveenzymeIDO1(human)(rec.)(His)(AG-40B-0161),compoundMMG-0358(AG-CR1-3630),averypotentandspecificinhibitorofIDO1,andprotocolsthatcanbeusedforIDO1enzymeactivityandIDO1inhibitionexperiments.
Bothcomponentscanbeusedinvitro:
• ForcellculturetostudytheeffectofhIDO1inacellularsystem.
• ForscreeningassaytosearchfornewinhibitorsofhIDO1.
