Adipogen/HSP70 (human) (rec.)/AG-40T-0272-C100/100 µg
商品编号：
AG-40T-0272-C100
品牌：
Adipogen Inc
市场价：
¥11540.00
美元价：
6924.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HeatShockProtein70;HSP70-1A;HSPA1A |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanHSP70(AccessionNr.AAD21816). |
| Crossreactivity | Human |
| MW | ~70kDa |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHEPES,pH8,100mMNaCl,5mMDTT. |
| OtherProductData | Use:Aninitialproteinconcentrationof2-3μMforinvitrouse. IMPORTANT:HSP40/DNAJB1,oranothersuitablecochaperone,isrequiredforHSP70/HSPA1AactivityandshouldbeusedataconcentrationthatisequimolartoHSP70/HSPA1A.Reactionconditionswillneedtobeoptimizedforeachspecificapplication. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
HeatShock70kDaProtein(HSP70),alsoknownasHeatShock70kDaProtein1A(HSPA1A),isa641aminoacid(aa)memberoftheHSP70familyofmolecularchaperoneswithapredictedmolecularweightof70kDa.HumanHSP70/HSPA1Ashares95%and97%aasequenceidentitywiththemouseandratorthologs,respectively.IthasanN-terminalnucleotide-bindingdomain,whichcontainsATPaseactivity,andaC-terminalsubstrate-bindingdomain.HSP70/HSPA1Apromotestheproperfoldingofnascentpolypeptidesandassistsintherefoldingofdenaturedproteins.However,ifeitheroftheseprocessesproceedstooslowlyorfails,HSP70/HSPA1AcaninteractwiththeHSP40co-chaperoneproteinandtheCHIP/STUB1ubiquitinligase(E3)topromoteubiquitinationanddegradationofthenascentpolypeptideordenaturedprotein.HSP70/HSPA1Acanberegulatedpost-translationallyviamultiplemechanisms,includingphosphorylation,ubiquitination,andmethylation.Forexample,unmethylatedHSP70/HSPA1Alocalizestothecytoplasm,butfollowingmethylationonLys561itisfoundonlyinthenucleus.Pathologically,HSP70/HSPA1Ahasbeenimplicatedinthepromotionofmultiplecancertypes.Conversely,itisthoughttoprotectagainstseveralneurodegenerativediseasesthatarecausedbytheaccumulationofmisfoldedproteins.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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