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Adipogen/IDO (human) (rec.) (His) (highly active)/AG-40B-0161-C050/50 µg
Adipogen/IDO (human) (rec.) (His) (highly active)/AG-40B-0161-C050/50 µg
商品编号：
AG-40B-0161-C050
品牌：
Adipogen Inc
市场价：
¥8400.00
美元价：
5040.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Indoleamine2,3-dioxygenase;INDO;IDO1;IDO-1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanIDO(aa1-403)isfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human |
| BIOLOGicalActivity | SpecificActivity:>100’000U/mgproteinwithL-tryptophanassubstrate(activityassaywithcatalase).Oneunitisdefinedastheamountofenzymethatproduces1nmolofN-formylkynurenine(NFK)perhour.FormoreinformationseeActivityTestProtocol. |
| MW | ~47kDa(SDS-PAGE) |
| Purity | ≥90%(SDS-PAGE) |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | Lotdependent |
| Formulation | Liquid.0.2μm-filteredsolutionin10mMTris,pH7.5,containing100mMNaCland20%glycerol. |
| OtherProductData | UniProtlinkP14902:Indoleamine2,3-dioxygenase(human) |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IDOisahemeenzymethatcatalyzesthefirstandrate-limitingstepinthemainpathwayofhumantryptophancatabolism,thekynureninepathway,causingdepletionoftryptophanwhichcanleadtohaltedgrowthofmicrobesaswellasTcells.IDOisanimmunecheckpointprotein,thoughttoplayaroleinavarietyofpathophysiologicalprocessessuchasantimicrobialandantitumordefense,neuropathology,immunoregulationandantioxidantactivity.Cancercellsareabletoevadetheimmunesystemisbyhijackingthecheckpointproteins.IncreasedIDOproteinlevelsdrivegrowtharrestandapoptosisoftheeffectorTcells,agroupofimmunecellsthatmediatetheimmunesystem’sabilitytodestroypathogens.ByreducingthenumberofeffectorTcells,IDOoverexpressionpreventstheimmunesystemfromeffectivelydestroyingcancercells.IDOoverexpressionhasbeenobservedinawiderangeofhumancancerssuchasprostatic,colorectal,pancreatic,cervical,gastric,ovarian,headorlungcancer.PhysiologicalIDOactivityhasbeenimplicatedinTcelltolerancetotumors,dysfunctionalselftoleranceinnon-obesediabetic(NOD)mice,andasaprotectivenegativeregulatorinautoimmunedisorders.BiologicalactiveIDOenzymecanbeusedforscreeningofIDOinhibitors,whichhaveshownpromisingantitumoractivityandappeartobesynergisticincombinationwithchemotherapyandotherformsofimmunotherapy.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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