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Adipogen/HpARI (Alarmin Release Inhibitor) (rec.) (His)/AG-40B-0178-C050/50 µg
| Product Details | |
|---|---|
| Synonyms | Heligmosomoides Polygyrus Alarmin Release Inhibitor |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Heligmosomoides polygyrus protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag. |
| Crossreactivity |
Human Mouse |
| Specificity |
Binds to human and mouse IL-33. |
| MW | ~40kDa |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | After reconstitution: 1mg/ml |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
Worm base HPBE_0000813301: Heligmosomoides polygyrus protein HpARI |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
HpARI is a protein secreted by the mouse parasite Heligmosomoides polygyrus. The mature protein HpARI, containing three predicted Complement Control Protein (CCP)-like modules (also known as Short Consensus Repeats (SCRs) or sushi-domains), suppresses type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. HpARI is a new type of reagent to prevent IL-33-mediated pathology.
- HpARI protein secreted by a helminth parasite suppresses interleukin-33: M. Osbourne, et al.; Immunity 47, 739 (2017)
