脂肪原/HES1（人类）（受体）（His）/AG-40A-0180-C050/50µg
商品编号：
AG-40A-0180-C050
品牌：
Adipogen Inc
市场价：
¥13800.00
美元价：
8280.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HairyandEnhancerofSplit1;TranscriptionFactorHES-1;ClassBBasicHelix-loop-helixProtein39;bHLHb39;HairyHomolog;Hairy-likeProtein;HRY;hHL |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanHES1(aa2-280)isfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human |
| MW | ~35kDa(SDS-PAGE) |
| Purity | ≥90%(SDS-PAGE) |
| Formulation | Liquid.0.2μm-filteredsolutionin55mMTRIS-Cl,pH8.2,containing150mMNaCl. |
| OtherProductData | UniProtlinkQ14469:HES-1(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
bHLHproteinsareessentialforneurogenesis,myogenesis,hematopoiesisandsexdetermination.HES1(HairyandEnhancerofSplit1)isabasicHelix-Loop-Helix(bHLH)transcriptionalrepressorregulatedbytheNotchpathwayandexpressedinvarioustissues.HES1iswellknownindevelopmentofdifferenttissues,particularlyendodermderivedendocrineorganslikepancreasandneuroendocrinecellsoflung.HES1controlsnormaldevelopmentbyregulatingproliferationanddifferentiationandsocellfate.Notchsignalingplaysbothoncogenicandtumorsuppressorrolesdependingoncelltype.IncontrasttoTcellacutelymphoblasticleukemia(ALL),whereNotchactivationpromotesleukemogenesis,inductionofNotchsignalinginBcellALL(B-ALL)leadstogrowtharrestandapoptosis.TheNotchtargetHES1issufficienttoreproducethistumorsuppressorphenotypeinB-ALLbyinteractingandactivatingPARP-1andregulatingproapoptoticsignals.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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