脂肪原/Fc（人类）：BAFF（人类）（记录）/AG-40B-0120-C500/500µg
商品编号：
AG-40B-0120-C500
品牌：
Adipogen Inc
市场价：
¥40000.00
美元价：
24000.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BLyS;TALL-1;CD257;BCellActivatingFactor;TNFSF13B;TumorNecrosisFactorLigandSuperfamilyMember13B |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | Thereceptor-bindingdomainofhumanBAFF(aa136-285)isfusedattheN-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseBAFF-R,TACIandBCMA. |
| BIOLOGicalActivity | RescuestheproductionofmaturefollicularandmarginalzoneBcells. -invitro:Additionof1-100ng/mlofFc-BAFFinducesBcellsurvivalinadose-dependentmanner. -invivo:Fc-BAFFtreatmentrescuesmatureBcelldevelopmentinBAFFdeficientmice.Miceareinjectedatday0with100µgFc-BAFFi.v.andatday14with50µgFc-BAFFi.p. |
| MW | ~50kDa(SDS-PAGE;reducingconditions) ~100kDa(SDS-PAGE;non-reducingconditions) ~300kDa(SDS-PAGE;native conditions;multimerizesandformshexamers) |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinAaffinitypurified. |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkQ9Y275:BAFF(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
BAFFismainlyproducedbyinnateimmunecellssuchasneutrophils,monocytes,macrophages,dendriticcells,folliculardendriticcells.Tcells,activatedBcells,somemalignantBcellsandalsonon-lymphoidcellslikeastrocytes,synoviocytesandepithelialcellscanalsoproduceBAFF.BAFFbindsthreedistinctreceptors(BAFF-R,TACIandBCMA)expressedpredominantlyonBcells,althoughactivatedTcellsalsoexpressBAFF-R.BAFFisamasterregulatorofperipheralBcellsurvival,andtogetherwithIL-6,promotesIgclass-switchingandplasmacelldifferentiation.BesidesitsmajorroleinBcellbiology,BAFFco-stimulatesactivatedTcells.DeregulatedexpressionofBAFFleadstoautoimmunedisordersinmice.Inhumans,elevatedlevelsofsolubleBAFFhavebeendetectedintheserumofpatientswithvariousautoimmunediseasessuchasSjoegrensyndrome,Rheumatoidarthritis(RA),Multiplesclerosis(MS)andSystemicLupusErythematosus(SLE).BAFFhasalsoincreasedlevelsinsomelymphoidcancers.
ProductReferences
- RescueofthematureBcellcompartmentinBAFF-deficientmicebytreatmentwithrecombinantFc-BAFF:L.K.Swee,etal.;Immunol.Lett.131,40(2010)
- SolubleBAFFlevelsinverselycorrelatewithperipheralBcellnumbersandtheexpressionofBAFFreceptors:M.Kreuzaler,etal.;J.Immunol.188,497(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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