脂肪原/Fc（人类）：FLT3配体（人类）（rec.）/AG-40B-0119-C010/10µg
商品编号：
AG-40B-0119-C010
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | FMS-likeTyrosineKinase3Ligand |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | Thereceptor-bindingdomainofhumanFLT3L(aa1-185)isfusedattheN-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseFLT3receptor. |
| BIOLOGicalActivity | Invitroandinvivogenerationofconventionalandplasmacytoiddendriticcells(DC).FLT3LincreasesinvivobothNKandDCcellsnumbersinthespleenwhenmiceareinjectedintraperitoneallywith2or10µg,dailyfor10days(slightlyhighereffectat10µg). |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinAaffinitypurified. |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBS(sterile). |
| OtherProductData | UniProtlinkP49771:FLT3L(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
FMS-liketyrosinekinase3ligand(FLT3L)actsasagrowthfactorthatincreasesthenumberofimmunecells(lymphocytes(BcellsandTcells))byactivatingthehematopoieticProgenitors.ItbindstoFLT3(CD135)whichisfoundonmultipotentprogenitor(MPP)andcommonlymphoidprogenitor(CLP)cellsinmice.FLT3Linducesthemobilizationofthehematopoieticprogenitorsandstemcellsinvivowhichmayhelpthesystemtokillcancercells.FLT3Liscrucialforsteady-statepDC(plasmacytoiddendriticcells)andcDC(classicaldendriticcells)development.DeficiencyofFLT3LcausesadramaticdecreaseinDCnumbers,whereasincreasingitsavailabilityincreaseinDCnumbers.
ProductReferences
- ExpansionofperipheralnaturallyoccurringTregulatorycellsbyFms-liketyrosinekinase3ligandtreatment:L.K.Swee,etal.;Blood113,6277(2009)
- Invivoevidenceforaninstructiveroleoffms-liketyrosinekinase-3(FLT3)ligandinhematopoieticdevelopment:P.Tsapogas,etal.;Haematologica99,638(2014)
- Flt3LigandRegulatestheDevelopmentofInnateLymphoidCellsinFetalandAdultMice:A.Baerenwaldt,etal.;J.Immunol.196,2561(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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