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Adipogen/EDAR (human):Fc (human) (rec.)/AG-40B-0116-3050/3 x 50 µg
Adipogen/EDAR (human):Fc (human) (rec.)/AG-40B-0116-3050/3 x 50 µg
商品编号：
AG-40B-0116-3050
品牌：
Adipogen Inc
市场价：
¥9600.00
美元价：
5760.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TumorNecrosisFactorReceptorSuperfamilyMemberEDAR;AnhidroticEctodysplasinReceptor1;DownlessHomolog;EDA-A1Receptor;EctodermalDysplasiaReceptor;Ectodysplasin-AReceptor |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanEDAR(aa27-183)isfusedattheC-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseEDA-A1. |
| BIOLOGicalActivity | InhibitsEDA-A1activity. |
| MW | ~50kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith50μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkQ9UNE0:EDAR(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheTNFfamilyligandectodysplasinA(EDA)anditsreceptorEDARarerequiredforproperdevelopmentofskinappendagessuchashair,teethandeccrinesweatglands.LossoffunctionmutationsintheEdagenecauseX-linkedhypohidroticectodermaldysplasia(XLHED),aconditionthatcanbeamelioratedinmiceanddogsbytimelyadmiNISTrationofrecombinantEDA.TheEdageneontheXchromosomeistranscribedasmultiplesplicevariants,onlytwoofwhichcodeforthereceptor-bindingC-terminalTNFhomologydomain.Thesetwovariantscodefor391-and389-aminoacid-longproteinscalledEDA1andEDA2.EDA1bindsEDAR,whereasEDA2bindstoanotherreceptor,XEDAR.ThebiologyofEDA2andXEDARisdistinctfromthatofEDA1.Indeed,XEDAR-deficientmicehavenoobviousectodermaldysplasiaphenotype,whereasmicedeficientinEDA,EDAR,orthesignalingadaptorproteinEDARADDalldisplayvirtuallyindistinguishableectodermaldysplasiaphenotypes,indicatingthepredominanceoftheEDA1-EDARaxisinthedevelopmentofskin-derivedappendages.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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