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Adipogen/DLL4 (human):Fc (human) (rec.)/AG-40A-0077Y-C050/50 µg
Adipogen/DLL4 (human):Fc (human) (rec.)/AG-40A-0077Y-C050/50 µg
商品编号：
AG-40A-0077Y-C050
品牌：
Adipogen Inc
市场价：
¥8200.00
美元价：
4920.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Delta-like Protein 4; Delta4 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence | Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| Specificity | Interacts with human Notch1 (as confirmed by flow cytometry). |
| Biological Activity | Inhibits adipogenesis of 3T3L-1 cells and mesenchymal stem cells (MSCs). Induces the Notch target gene HES-1 when coated on a plate at 1µg/ml. |
| MW | ~80kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration |
10µg size: 0.1mg/ml after reconstitution. 50µg size: 1mg/ml after reconstitution. |
| Reconstitution |
10µg size: Reconstitute with 100µl sterile water. 50µg size: Reconstitute with 50µl sterile water. |
| Formulation | Lyophilized. Contains PBS + 0.5 % Trehalose. |
| Other Product Data | UniProt link Q9NR61: DLL4 (human) [Precursor] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
Product References
- Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions: I. Van de Walle, et al.; Blood 117, 4449 (2011)
- Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6: K.P. Mouillesseaux, et al.; Nat. Commun. 7, 13247 (2016)
- Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE 12, e0177516 (2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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