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Adipogen/DLL4 (human):Fc (human) (rec.)/AG-40A-0077Y-C010/10 µg
Adipogen/DLL4 (human):Fc (human) (rec.)/AG-40A-0077Y-C010/10 µg
商品编号：
AG-40A-0077Y-C010
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Delta-likeProtein4;Delta4 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | SignalpeptideandextracellulardomainofhumanDLL4(aa1-529)arefusedattheC-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Human |
| Specificity | InteractswithhumanNotch1(asconfirmedbyflowcytometry). |
| BIOLOGicalActivity | InhibitsADIpogenesisof3T3L-1cellsandmesenchymalstemcells(MSCs).InducestheNotchtargetgeneHES-1whencoatedonaplateat1µg/ml. |
| MW | ~80kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 10µgsize:0.1mg/mlafterreconstitution. 50µgsize:1mg/mlafterreconstitution. |
| Reconstitution | 10µgsize:Reconstitutewith100µlsterilewater. 50µgsize:Reconstitutewith50µlsterilewater. |
| Formulation | Lyophilized.ContainsPBS+0.5%Trehalose. |
| OtherProductData | UniProtlinkQ9NR61:DLL4(human)[Precursor] |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheNotchliganddelta-likeprotein4(DLL4)isexpressedhighlyandselectivelywithinthearterialendotheliumandhasbeenshowntofunctionasaligandforNotch1andNotch4.ItisinducedbyVEGFasanegativefeedbackregulatorandactstopreventoverexuberantangiogenicsprouting,promotingthetimelyformationofawelldifferentiatedvascularnetwork.DLL4-Notch1signalingregulatestheformationofappropriatenumbersoftipcellstocontrolvesselsproutingandbranchinginthemouseretina.
ProductReferences
- Jagged2actsasaDelta-likeNotchligandduringearlyhematopoieticcellfatedecisions:I.VandeWalle,etal.;Blood117,4449(2011)
- NotchregulatesBMPresponsivenessandlateralbranchinginvesselnetworksviaSMAD6:K.P.Mouillesseaux,etal.;Nat.Commun.7,13247(2016)
- Notchligandsregulatethemusclestem-likestateexvivobutarenotsufficientforretainingregenerativecapacity:H.Sakai,etal.;PLoSONE12,e0177516(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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