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Adipogen/Clusterin (secretory form) (human) (rec.)/AG-40A-0050Y-C050/50 µg
Adipogen/Clusterin (secretory form) (human) (rec.)/AG-40A-0050Y-C050/50 µg
商品编号：
AG-40A-0050Y-C050
品牌：
Adipogen Inc
市场价：
¥6300.00
美元价：
3780.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TRPM-2;ApolipoproteinJ;APO-J;CLI;CLU;SGP-2 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | Signalpeptidesequenceandthehumansecretoryclusterin(aa1-449)arefusedattheC-terminustoaFLAG®-tag. |
| Crossreactivity | Human |
| MW | 80kDa(undernon-reducingconditions);39kDaand40kDa(underreducingconditions)(bySDS-PAGE). |
| Purity | ≥90%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | Afterreconstitution: for10µgsize:0.1mg/ml for50µgsize:1mg/ml |
| Reconstitution | 10µgsize:Reconstitutewith100µlsterilewater. 50µgsize:Reconstitutewith50µlsterilewater. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniprotlinkP10909:Clusterin(human)[Precursor] FLAGisaregisteredtrademarkofSigma-AldrichCo. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Clusterinshareshomologywiththesmallheatshockproteinfamilyofmolecularchaperones.Thematuresecretedformoftheproteinisaglycosylated,80kDadisulfide-linkedheterodimerofαandβsubunits(producedbyinternalcleavage).Clusterinisexpressedinvirtuallyalltissuesandfoundinallhumanfluids.Itisinvolvedinnumerousphysiologicalprocessesimportantforcarcinogenesisandtumorgrowth,includingapoptoticcelldeath,cellcycleregulation,DNArepair,celladhesion,tissueremodeling,lipidtransportation,membranerecyclingandimmunesystemregulation.Clusterinalsoexistsasanuclearprotein.ThesecretedformofClusterinhasextracellularchaperoneandanti-apoptoticactivitieswhilethenuclearformactsasaproapoptoticfactor.
ProductReferences
- Clusterininducesmatrixmetalloproteinase-9expressionviaERK1/2andPI3K/Akt/NF-κBpathwaysinmonocytes/macrophages:Y.-J.Shim,etal.;J.Leuk.Biol.90,761(2011)
- ClusterinandLRP2arecriticalcomponentsofthehypothalamicfeedingregulatorypathway:S.Y.Gil,etal.;Nat.Commun.4,1862(2013)
- Clusterin/ApoJenhancescentralleptinsignalingthroughLrp2-mediatedendocytosis:K.Byun,etal.;EMBORep.15,801(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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