Adipogen/CHIP (human) (rec.)/AG-40T-0230-C050/50 µg
商品编号：
AG-40T-0230-C050
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | E3Ubiquitin-proteinLigaseCHIP;C-terminusofHsc70InteractingProtein;HSPABP2;NY-CO-7;SDCCAG7;UBOX1;CLL-associatedAntigenKW-8;STIP1HomologyandUBox-containingProtein1;STUB1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanCHIP(AccessionNr.Q9UNE7). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,100mMNaCl,10%Glycerol(v/v),5mMDTT. |
| OtherProductData | Use:Ubiquitinligase(E3)thatfunctionsdownstreamofaubiquitin-activating(E1)enzymeandaubiquitin-conjugating(E2)enzymetoconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
STIP1HomologyandU-boxContainingProtein1(STUB1),alsoknownascarboxylterminusofHsp70-interactingprotein(CHIP),isacytoplasmicproteinthatfunctionsasaU-boxubiquitinligase(E3).Itishighlyexpressedinstriatedmuscleandbrainandhasbeenobservedatlowerlevelsinotherorgansincludingthepancreas,lung,liverandkidney.STUB1/CHIPis303aminoacids(aa)inlengthwithapredictedmolecularweightof34.8kDa.HumanSTUB1/CHIPshares97%aasequenceidentitywiththemouseorthologbutonly67%sequenceidentitywiththeratortholog.Itconsistsofthree34aaN-terminaltetratricopeptiderepeat(TRP)domains(aa26-127)thatareresponsIBLeforprotein-proteininteractionsandaC-terminalU-boxdomain(aa226-300)thatparticipatesinubiquitination.AcentraldomaincontainingchargedresiduesliesbetweentheTRPandU-boxdomainsandisthoughttobenecessaryforTRP-dependentinteractions.STUB1/CHIPparticipatesinintracellularproteinfolding/refoldinganddegradation.Itcomplexeswithseveralmolecularchaperoneproteins,includingHSP70/HSPA1A,HSC70,andHSP90andmodulatestheiractivity.Italsofacilitatestheubiquitinationofchaperonesubstrates,includingnascentCFTR,phosphorylatedTau,p53,PTEN,Synuclein-α,andβ-APP,promotingtheirdegradation.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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