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Adipogen/cIAP-1 (human) (rec.) (His)/AG-40T-0551-C050/50 µg
Adipogen/cIAP-1 (human) (rec.) (His)/AG-40T-0551-C050/50 µg
商品编号：
AG-40T-0551-C050
品牌：
Adipogen Inc
市场价：
¥5820.00
美元价：
3492.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HIAP-2;InhibitorofCancerProtein2;IAP-2;RINGFingerProtein48;TNFR2-TRAF-signalingComplexProtein2 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumancIAP-1(AccessionNr.Q13490)fusedtoaN-terminalHis10-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,500mMNaCl,20%Glycerol(v/v),5mMTCEP. |
| OtherProductData | Use:RINGfingerubiquitinligase(E3)thatfunctionsdownstreamofaUbiquitinactivating(E1)enzymeandaUbiquitin-conjugating(E2)enzymetoconjugateUbiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.21µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Multi-functionalproteinwhichregulatesnotonlycaspasesandcancer,butalsomodulatesinflammatorysignalingandimmunity,mitogenickinasesignalingandcellproliferation,aswellascellinvasionandmetastasis.ActsasanE3ubiquitin-proteinligaseregulatingNF-κ-Bsignalingandregulatesbothcanonicalandnon-canonicalNF-κ-Bsignalingbyactinginoppositedirections;asapositiveregulatorofthecanonicalpathwayandsuppressesconstitutiveactivationofnon-canonicalNF-κ-Bsignaling.ThetargetproteinsforitsE3ubiquitin-proteinligaseactivityinclude:RIPK1,RIPK2,RIPK3,RIPK4,CASP3,CASP7,CASP8,TRAF2,DIABLO/SMAC,MAP3K14/NIK,MAP3K5/ASK1,IKBKG/NEMO,IKBKEandMXD1/MAD1.CanalsofunctionasanE3ubiquitin-proteinligaseoftheNEDD8conjugationpathway,targetingeffectorcaspasesforneddylationandinactivation.ActsasanimportantregulatorofinnateimmunesignalingviaregulationofToll-likereceptors(TLRs),Nod-likereceptors(NLRs)andRIG-Ilikereceptors(RLRs).Protectscellsfromspontaneousformationoftheripoptosome,alargemulti-proteincomplexthathasthecapabilitytokillcancercellsinacaspase-dependentandcaspase-independentmanner.SuppressesripoptosomeformationbyubiquitinatingRIPK1andCASP8.CanstimulatethetranscriptionalactivityofE2F1.Playsaroleinthemodulationofthecellcycle.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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