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Adipogen/CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-120PDL1-C100/100 µg
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Adipogen/CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)/CHI-MF-120PDL1-C100/100 µg
商品编号：
CHI-MF-120PDL1-C100
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PD-L1;ProgrammedCellDeath1LigandProtein1;PDCD1Ligand1;B7-H1;PDL1 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofmouseCD274[B7-H1](aa19-237)isfusedtotheN-terminusoftheFcregionofamutantmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | ShowsthebiologicalfunctionoftheCD274moietyandexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceNP_068693.1:CD274(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Programmeddeathligand1(PD-L1,B7-H1orCD274)isamemberofthegrowingB7familyofimmuneproteinsthatprovidesignalsforbothstimulatingandinhibitingTcellactivation.CD274hasbeenidentifiedasoneoftwoligandsforprogrammeddeath1(PD-1),amemberoftheCD28familyofimmunoreceptors.CD274iswidelyexpressedinseveralorganssuchasheart,skeletalmuscle,placentaandlung,andinloweramountsinthymus,spleen,kidneyandliver.CD274expressionisupregulatedinasmallfractionofactivatedTandBcellsandamuchlargerfractionofactivatedmonocytes.CD274expressionisalsoinducedindendriticcellsandkeratinocytesafterIFN-γstimulation.CD274expressionisalsoupregulatedinavarietyoftumorcelllines.InteractionofCD274withPD-1resultsininhibitionofTCRmediatedproliferationandcytokineproduction,suggestinganinhibitoryroleinregulatingimmuneresponses..TheCD274-PD-1pathwayisinvolvedinthenegativeregulationofsomeimmuneresponsesandmayplayanimportantroleintheregulationofperipheraltolerance.
ProductReferences
- ProgrammedDeath-1Ligand1InteractsSpecificallywiththeB7-1CostimulatoryMoleculetoInhibitTCellResponses:M.J.Butte,etal.;Immunity27,111(2007)
- StimulationofthePD-1/PDL-1T-cellco-inhibitorypathwayiseffectiveintreatmentofexperimentalautoimmuneglomerulonephritis:J.Reynolds,etal.;Nephrol.Dial.Transplant.27,1343 (2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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