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Adipogen/CD152 [CTLA-4] (mouse):Fc (mouse) (rec.)/CHI-MF-110A4-M001/1 mg
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Adipogen/CD152 [CTLA-4] (mouse):Fc (mouse) (rec.)/CHI-MF-110A4-M001/1 mg
商品编号：
CHI-MF-110A4-M001
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CTLA-4 |
| ProductType | Protein |
| Properties | |
| Source/Host | NS1cells |
| Sequence | TheextracellulardomainofmouseCD152[CTLA-4](aa38-160)isfusedtotheN-terminusoftheFcregionofmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | BindsbothCD80(B7-1)andCD86(B7-2)withhighaffinityandinhibitsCD28signalingcompetitively.Killsthetargetcellcompletely. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat1mg/mlinsterilewater. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_033973.2:CD152(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD152[CTLA-4]andCD28,togetherwiththeirligandsB7-1andB7-2,constituteoneofthedominantcostimulatorypathwaysthatregulateTandBcellresponses.CD152andCD28arestructurallyhomologousmoleculesthataremembersoftheimmunoglobulin(Ig)genesuperfamily.BothCD152andCD28arecomposedofasingleIgV-likeextracellulardomain,atransmembranedomainandanintracellulardomain.CD152andCD28arebothexpressedonthecellsurfaceasdisulfide-linkedhomodimersorasmonomers.CD152wasoriginallyidentifiedasagenethatwasspecificallyexpressedbycytotoxicTlymphocytes.However,CD152transcriptshavesincebeenfoundinbothTh1andTh2,andCD4+andCD8+Tcellclones.Whereas,CD28expressionisconstitutiveonthesurfacesof95%ofCD4+Tcellsand50%ofCD8+TcellsandisdownregulateduponTcellactivation,CD152expressionisupregulatedrapidlyfollowingTcellactivationandpeaksapproximately24hoursfollowingactivation.AlthoughbothCD152andCD28canbindtothesameligands,CD152bindstoB71andB72with20-100-foldhigheraffinitythanCD28.
ProductReferences
- ExvivocoatingofisletcellallograftswithmurineCTLA4/Fcpromotesgrafttolerance:W.Steurer,etal.;J.Immunol.155,1165(1995)
- CTLA4IgpreventslymphoproliferationandfatalmultiorgantissuedestructioninCTLA-4-deficientmice:E.A.Tivol,etal.;J.Immunol.158,5091(1997)
- Cuttingedge:therelatedmoleculesCD28andinducIBLecostimulatordeliverbothuniqueandcomplementarysignalsrequiredforoptimalTcellactivation:J.A.Gonzalo,etal.;J.Immunol.166,1(2001)
- RecombinantAdenovirusCoexpressingCovalentPeptide/MHCClassIIComplexandB7-1:InVitroandInVivoActivationofMyelinBasicProtein-SpecificTCells:J.Chen,etal.;J.Immunol.167,1297(2001)
- CuttingEdge:InducedIndoleamine2,3DioxygenaseExpressioninDendriticCellSubsetsSuppressesTCellClonalExpansion:A.L.Mellor,etal.;J.Immunol.171,1652(2003)
- Tim-3inhibitsThelpertype1-mediatedauto-andalloimmuneresponsesandpromotesimmunologicaltolerance:A.Sanchez-Fueyo,etal.;Nat.Immunol.4,1093(2003)
- InVitroandInVivoEvaluationofStaphylococcalSuperantigenPeptideAntagoNISTs:G.Rajagopalan,etal.;Infect.Immun.v72,6733(2004)
- Blockinginducibleco-stimulatorintheabsenceofCD28impairsTh1andCD25+regulatoryTcellsinmurinecolitis:Y.P.deJong,etal.;Internat.Immunol.16,205(2004)
- SpecificsubsetsofmurinedendriticcellsacquirepotentTcellregulatoryfunctionsfollowingCTLA4-mediatedinductionofindoleamine2,3dioxygenase:A.L.Mellor,etal.;Internat.Immunol.16,1391(2004)
- AmutantB7-1/IgfusionproteinthatselectivelybindstoCTLA-4amelioratesanti-tumorDNAvaccinationandcountersregulatoryTcellactivity:R.Chakrabarti,etal.;Vaccine23,4553(2005)
- ProgrammedDeath-1Ligand1InteractsSpecificallywiththeB7-1CostimulatoryMoleculetoInhibitTCellResponses:M.J.Butte,etal.;Immunity27,111(2007)
- MonovalentantibodyscFvfragmentsselectedtomodulateT-cellactivationbyinhibitionofCD86–CD28interaction:R.Kolly,etal.;Prot.Engin.Des.Sel.20,91(2007)
- PivotalAdvance:CTLA-4+Tcellsexhibitnormalantiviralfunctionsduringacuteviralinfection:H.-P.Raué&M.K.Slifka;J.Leuk.Biol.81,1165(2007)
- TargetedCleavageofSignalingProteinsbyCaspase3InhibitsTCellReceptorSignalinginAnergicTCells:I.Puga,etal.;Immunity29,193(2008)
- TheTumorNecrosisFactor-FamilyReceptorDR3isEssentialforDiverseT-CellMediatedInflammatoryDiseases:F.Meylan,etal.;Immunity29,79(2008)
- ImprovedimmunologicaltolerancefollowingcombinationtherapywithCTLA-4/IgandAAV-mediatedPD-L1/2musclegenetransfer:S.Adriouch,etal.;Front.Microbiol.2,199(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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