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Adipogen/CD152 [CTLA-4] (human):Fc (human) (rec.) (non-lytic)/CHI-HF-220A4-C500/500 µg
![Adipogen/CD152 [CTLA-4] (human):Fc (human) (rec.) (non-lytic)/CHI-HF-220A4-C500/500 µg](https://www.ebiomall.cn/images/adipogen/adipogen_logo_bw_2.png){kind=logo}
Adipogen/CD152 [CTLA-4] (human):Fc (human) (rec.) (non-lytic)/CHI-HF-220A4-C500/500 µg
商品编号：
CHI-HF-220A4-C500
品牌：
Adipogen Inc
市场价：
¥5400.00
美元价：
3240.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CTLA-4;CytotoxicT-lymphocyteProtein4 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanCD152[CTLA-4](aa37-160)isfusedtotheN-terminusoftheFcregionofamutanthumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | MeasuredbyitsABIlitytoinhibitIL-2secretionbystimulatedJurkathumanacuteTcellleukemiacells. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceNP_005205.2:CD152(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD152(CTLA-4)andCD28,togetherwiththeirligandsB7-1andB7-2,constituteoneofthedominantcostimulatorypathwaysthatregulateTandBcellresponses.CD152andCD28arestructurallyhomologousmoleculesthataremembersoftheimmunoglobulin(Ig)genesuperfamily.BothCD152andCD28arecomposedofasingleIgV-likeextracellulardomain,atransmembranedomainandanintracellulardomain.CD152andCD28arebothexpressedonthecellsurfaceasdisulfide-linkedhomodimersorasmonomers.CD152wasoriginallyidentifiedasagenethatwasspecificallyexpressedbycytotoxicTlymphocytes.However,CD152transcriptshavesincebeenfoundinbothTh1andTh2,andCD4+andCD8+Tcellclones.Whereas,CD28expressionisconstitutiveonthesurfacesof95%ofCD4+Tcellsand50%ofCD8+TcellsandisdownregulateduponTcellactivation,CD152expressionisupregulatedrapidlyfollowingTcellactivationandpeaksapproximately24hoursfollowingactivation.AlthoughbothCD152andCD28canbindtothesameligands,CD152bindstoB71andB72with20-100-foldhigheraffinitythanCD28.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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