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脂肪原/CD152[CTLA-4]（人类）：Fc（人类）（rec.）/CHI-HF-210A4-C500/500µg
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脂肪原/CD152[CTLA-4]（人类）：Fc（人类）（rec.）/CHI-HF-210A4-C500/500µg
商品编号：
CHI-HF-210A4-C500
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CTLA-4 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanCD152[CTLA-4](aa37-160)isfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | BindsbothCD80(B7-1)andCD86(B7-2)withhighaffinityandinhibitsCD28signalingcompetitively.Killsthetargetcellcompletely. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat1mg/mlinsterilewater. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_005205.2:CD152(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD152[CTLA-4]andCD28,togetherwiththeirligandsB7-1andB7-2,constituteoneofthedominantcostimulatorypathwaysthatregulateTandBcellresponses.CD152andCD28arestructurallyhomologousmoleculesthataremembersoftheimmunoglobulin(Ig)genesuperfamily.BothCD152andCD28arecomposedofasingleIgV-likeextracellulardomain,atransmembranedomainandanintracellulardomain.CD152andCD28arebothexpressedonthecellsurfaceasdisulfide-linkedhomodimersorasmonomers.CD152wasoriginallyidentifiedasagenethatwasspecificallyexpressedbycytotoxicTlymphocytes.However,CD152transcriptshavesincebeenfoundinbothTh1andTh2,andCD4+andCD8+Tcellclones.Whereas,CD28expressionisconstitutiveonthesurfacesof95%ofCD4+Tcellsand50%ofCD8+TcellsandisdownregulateduponTcellactivation,CD152expressionisupregulatedrapidlyfollowingTcellactivationandpeaksapproximately24hoursfollowingactivation.AlthoughbothCD152andCD28canbindtothesameligands,CD152bindstoB71andB72with20-100-foldhigheraffinitythanCD28.
ProductReferences
- Long-termsurvivalofxenogeneicpancreaticisletgraftsinducedbyCTLA4lg:D.J.Lenschow,etal.;Science257,789(1992)
- InductionofperipheralTcelltoleranceinvivorequiresCTLA-4engagement:V.L.Perez,etal.;Immunity6,411(1997)
- LigationofB7-1/B7-2byHumanCD4TCellsTriggersIndoleamine2,3-DioxygenaseActivityinDendriticCells:D.H.Munn,etal.;J.Immunol.172,4100(2004)
- CD28deliversauniquesignalleADIngtotheselectiverecruitmentofRelAandp52NF-kappaBsubunitsonIL-8andBcl-xLgenepromoters:B.Marinari,etal.;PNAS101,6098(2004)
- AnengineeredlipocalinspecificforCTLA-4revealsacombiningsitewithstructuralandconformationalfeaturessimilartoantibodies:D.Schönfeld,etal.;PNAS106,8198(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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