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Adipogen/CD137 (human):Fc (mouse) (rec.)/CHI-HF-211CD137-C100/100 µg
Adipogen/CD137 (human):Fc (mouse) (rec.)/CHI-HF-211CD137-C100/100 µg
商品编号：
CHI-HF-211CD137-C100
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TumorNecrosisFactorReceptorSuperfamilyMember9;TNFRSF9;4-1BB;4-1BBLigandReceptorTCell;Antigen4-1BBHomolog;TCellAntigenILA;CD137Antigen;CDw137;ILA;MGC2172 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofhumanCD137[4-1BB](aa19-184)isfusedtotheN-terminusoftheFcregionofmouseIgG2a. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | MeasuredbyitsbindingABIlityinafunctionalELISA. |
| MW | ~55kDa(SDS-PAGE) |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <5eu g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitute100µgvialwith100µlsterilewatertoaconcentrationof1mg/ml. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceAAH06196.1:CD137(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
HumanCD137(4-1BB)isacostimulatorymoleculeofthetumornecrosisfactor(TNF)receptorsuperfamily.Theglycoprotein4-1BBisexpressedmainlyonactivatedCD4+andCD8+Tcellsandbindstoahigh-affinityligand(4-1BBL)expressedonseveralantigen-presentingcellssuchasmacrophagesandactivatedBcells.Uponligandbinding,4-1BBisassociatedwiththetumorreceptor-associatedfactors(TRAF),theadaptorproteinandmediatesdownstreamsignalingeventsincludingtheactivationofNF-κBandcytokineproduction.4-1BBsignalingeitherbybindingto4-1BBLorbyantibodyligationdeliverssignalsforTcellactivationandgrowthaswellasmonocyteproliferationandBcellsurvival,andplaysaimportantroleintheamplificationofTcell-mediatedimmuneresponses.Incontrast,itcanalsoenhanceactivation-inducedTcellapoptosiswhentriggeredbyengagementoftheTCR/CD3complex.Inaddition,the4-1BB/4-1BBLcostimulatorypathwayhasbeenshowntoaugmentsecondaryCTLresponsestoseveralvirusesandincreaseantitumorimmunity.4-1BBisthereforeapromisingcandidateforimmunotherapyofhumancancer.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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