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Adipogen/CD112R (mouse):Fc (human) (rec.)/AG-40B-0170-C010/10 µg
| ProductDetails | |
|---|---|
| Synonyms | CD112Receptor;PoliovirusReceptor-relatedImmunoglobulinDomain-containingProtein;TransmembraneProteinPVRIG |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofmouseCD112R(aa28-165)isfusedattheC-terminustotheFcportionofhumanIgG1. |
| Crossreactivity | Mouse |
| BIOLOGicalActivity | BindstotheligandmouseCD112(PVRL2,Nectin-2)withanEC50of5nM. |
| MW | ~48-50kDa(SDS-PAGE) |
| Purity | ≥90%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CD112(alsocalledNectin-2orpoliovirusreceptor-related2protein)isatypeItransmembraneglycoproteinandamemberoftheIggenesuperfamily(IGSF).CD112/Nectin-2functionsasanadhesionmoleculeinvolvedintheformationofcelljunctionsandinteractionswithotherNectin-familymolecules.Nectin-2isaalsoasurfaceMarkerofsomeendothelialcellsandregulatesmigration,proliferationandangiogenesis.CD112functionsasanimmunecheckpointregulatorbymodulatingTcellsignaling,eitherasacostimulatorofTcellfunction,orasacoinhibitorofTcellsproliferationbybindingtothereceptorsCD226orTIGIT(TcellIgandimmunoreceptortyrosine-basedinhibitorymotif(ITIM)domain),respectively.ThebindingofCD112ligandtothesereceptorsisweakcomparedtoCD155.Recently,anewreceptorofCD112,calledCD112RorPVRIG(Poliovirusreceptor-relatedimmunoglobulindomain-containingprotein)hasbeencharacterized,showinghighaffinitytoCD112.CD112RisanewcoinhibitoryreceptorofthePVRfamilyforhumanTcells,inhibitingTCR-mediatedsignalsuponbindingtoCD112/Nectin-2.CD112RispreferentiallyexpressedinTlymphocytesandNKcells.CancercellsevadeimmuneresponsesasaresultofanimmunosuppressivetumormicroenvironmentandCD112R,byplayingaroleintheregulationoftheimmunesystem,couldbeanewattractivecancerimmunotherapytarget.
