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Adipogen/Beclin-1 (human) (rec.) (His)/AG-40B-0140-5010/5 x 10 µg
Adipogen/Beclin-1 (human) (rec.) (His)/AG-40B-0140-5010/5 x 10 µg
商品编号：
AG-40B-0140-5010
品牌：
Adipogen Inc
市场价：
¥17400.00
美元价：
10440.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ATG6;BECN1;GT197 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Recombinanthumanbeclin-1(aa1-450)isfusedthroughathrombinlinkerto6xHis-tag. |
| Crossreactivity | Human |
| MW | ~54kDa(SDS-PAGE) |
| Purity | ≥85%(SDS-PAGE) |
| PurityDetail | Affinitypurified. |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutein100μlsterilewater. |
| Formulation | Lyophilizedfrom25mMTRIS-HCl,pH8.0,containing100mMglycine. |
| OtherProductData | NCBIReferenceNM_003766.3:BECN1(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Beclin-1(Bcl-2interactingcoiled-coilprotein;ATG6)isamultifunctionalprotein,well-knownasakeyregulatorofautophagyandrequiredfortheinitiationstepinautophagosomeformation.Itinteractswithseveralcofactors(Atg14L,UVRAG,Bif-1,rubicon,Ambra1,HMGB1,nPIST,VMP1,SLAM,IP3R,PINKandsurvivin)toregulatethelipidkinasePI3KproteinandpromoteformationofPIK3C3/VPS34-containingcomplexes.Theseinteractionsinduceautophagy,whichisaprocessofprogrammedcellsurvivalincreasedduringperiodsofcellstressandextinguishedduringthecellcycle.FurThermore,beclin-1isimplicatedinnumerousBIOLOGicalprocesses,includingadaptationtostress,development,endocytosis,cytokinesis,immunity,infection,tumOrigenesis,agingandcelldeath.Beclin-1istightlyregulatedbydiversemechanisms,suchasepigeneticsilencing,microRNAregulation,post-translationalmodificationsandprotein-proteininteractions.Multiplediseasesareassociatedwithdeficiencyormalfunctionofbeclin-1,includingcancerandneurodegeneration.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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