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Adipogen/Ataxin-3 (human) (rec.) (His)/AG-40T-0224-C050/50 µg
Adipogen/Ataxin-3 (human) (rec.) (His)/AG-40T-0224-C050/50 µg
商品编号：
AG-40T-0224-C050
品牌：
Adipogen Inc
市场价：
¥3860.00
美元价：
2316.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ataxin-3;Machado-JosephDiseaseProtein1;SpinocerebellarAtaxiaType3Protein;ATXN3;ATX3,MJD,MJD1,SCA3 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanataxin-3(AccessionNr.AAH33711)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaCl,Glycerol,EDTAandDTT. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialenzymeconcentrationof1-5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ataxin-3,alsoknownasMachado-JosephDisease(MJD)Protein1andSpinocerebellarAtaxiaType3,isa364aminoacid(aa),ubiquitouslyexpressedcytoplasmicandnuclearproteinwithapredictedmolecularweightof42kDa.Ataxin-3functionsasadeubiquitinatingenzyme.HumanAtaxin-3shares87%and86%aasequenceidentitywithmouseandratAtaxin-3,respectively.Full-lengthAtaxin-3containsaN-terminaljosephindomain,twoubiquitininteractingmotifs,andavariableC-terminusconsistingofapolyglutaminestretchandtail.Asadeubiquitinatingenzyme,Ataxin-3playsacriticalroleinaffectingtheubiquitinationstatusofproteinsforqualitycontrolandothercellularpathways.Inturn,theubiquitinationofAtaxin-3wasshowntoenhanceitscapacitytocleaveubiquitinchains.Byopposingtheactionsoftheubiquitin-conjugating(E2)enzymeUBE2W,Ataxin-3isbelievedtocontroltheactivityoftheubiquitinligase(E3)C-terminusofHsp70InteractingProtein(CHIP).CHIPbindstoproteinchaperonesandrepresentsanimportantmolecularlinkbetweenthechaperoneandubiquitin-proteasomesystem.ExpressionofmurineAtaxin-3isthoughttobeimportantformyogenesis,aneffectthatisdependentontheregulationofIntegrinα5levels.MutationsintheATXN3genearethecauseofMJD,alsoknownasspinocerebellarataxia3,anautosomaldominantneurodegenerativedisordercharacterizedbynuclearaggregationofAtaxin-3moleculesfeaturinganexpandedpolyglutaminetrac.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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