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Adipogen/APRIL (mouse) (H98) (multimeric) (rec.)/AG-40B-0035-C010/10 µg
Adipogen/APRIL (mouse) (H98) (multimeric) (rec.)/AG-40B-0035-C010/10 µg
商品编号：
AG-40B-0035-C010
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MultimericAPRIL™;ACRP30headless:APRIL;ACRP30headless:CD256;ACRP30headless:TNFSF13;ACRP30headless:A-proliferation-inducingLigand: |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofmouseAPRIL(aa98-232)isfusedattheN-terminustomouseACRP30headless(aa18-110)andaFLAG®-tag. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseBCMAandTACI.Doesnotbindtoproteoglycans. |
| BIOLOGicalActivity | StimulatesBcellproliferation. |
| MW | ~32kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01EU/μgpurifiedprotein(LALtest;Lonza). |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS+0.5%Trehalose. |
| OtherProductData | UniProtlinkQ9D777:APRIL(mouse) FLAGisaregisteredtrademarkofSigma-AldrichCo. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
APRILisacytokinethatbelongstotheTNFsuperfamilyandbindstoTACIandBCMA.Itisimplicatedintheregulationoftumorcellgrowth,isinvolvedinmonocyte/macrophage-mediatedimmunologicalprocessesandfunctionsasanimportantsurvivalfactorforplasmablastsandbonemarrowplasmacells.MultimericAPRIL™isahighactivityconstructinwhichtwotrimericAPRILligandsareartificiallylinkedviathecollagendomainofACRP30.ThisconstructveryeffectivelystimulatesproliferationBcell.Abasicaminoacidsequence(QKQKKQ)closetotheNH2terminusofAPRILisrequiredforbindingtonegativelychargedsulfatedglycosaminoglycansidechainsofproteoglycans.ProteoglycansmediatebindingofAPRILtotumorcellsaswellasprimarylymphoidcells.
ProductReferences
- SelectiveAPRILblockadedelayssystemiclupuserythematosusinmouse:B.Huard,etal.;PLoSOne7,e31837(2012)
- γ-secretasedirectlyshedsthesurvivalreceptorBCMAfromplasmacells:S.A.Laurent,etal.;DissertationLMU(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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