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Adipogen/APRIL (human) (multimeric) (rec.)/AG-40B-0017-C010/10 µg
Adipogen/APRIL (human) (multimeric) (rec.)/AG-40B-0017-C010/10 µg
商品编号：
AG-40B-0017-C010
品牌：
Adipogen Inc
市场价：
¥5900.00
美元价：
3540.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MultimericAPRIL™;ACRP30headless:APRIL;ACRP30headless:CD256;ACRP30headless:TNFSF13;ACRP30headless:A-proliferation-inducingLigand: |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofhumanAPRIL(aa88-233)isfusedattheN-terminustohumanACRP30headless(aa16-108)andaFLAG®-tag. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseBCMAandTACI.Bindstoproteoglycans. |
| BIOLOGicalActivity | StimulatesBcellproliferation. |
| MW | ~34kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01EU/μgpurifiedprotein(LALtest;Lonza). |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkO75888:APRIL(human) FLAGisaregisteredtrademarkofSigma-AldrichCo. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
APRILisacytokinethatbelongstotheTNFsuperfamilyandbindstoTACIandBCMA.Itisimplicatedintheregulationoftumorcellgrowth,isinvolvedinmonocyte/macrophage-mediatedimmunologicalprocessesandfunctionsasanimportantsurvivalfactorforplasmablastsandbonemarrowplasmacells.
MultimericAPRIL™isahighactivityconstructinwhichtwotrimericAPRILligandsareartificiallylinkedviathecollagendomainofACRP30.ThisconstructveryeffectivelystimulatesproliferationBcell.Abasicaminoacidsequence(QKQKKQ)closetotheNH2terminusofAPRILisrequiredforbindingtonegativelychargedsulfatedglycosaminoglycansidechainsofproteoglycans.ProteoglycansmediatebindingofAPRILtotumorcellsaswellasprimarylymphoidcells.
MultimericAPRIL™isahighactivityconstructinwhichtwotrimericAPRILligandsareartificiallylinkedviathecollagendomainofACRP30.ThisconstructveryeffectivelystimulatesproliferationBcell.Abasicaminoacidsequence(QKQKKQ)closetotheNH2terminusofAPRILisrequiredforbindingtonegativelychargedsulfatedglycosaminoglycansidechainsofproteoglycans.ProteoglycansmediatebindingofAPRILtotumorcellsaswellasprimarylymphoidcells.
ProductReferences
- DCsinduceCD40-independentimmunoglobulinclassswitchingthroughBLySandAPRIL:M.B.Litinskiy,etal.;Nat.Immunol.3,822(2002)
- APRILmodulatesBandTcellimmunity:J.V.Stein,etal.;J.Clin.Invest.109,1587(2002)
- PotentialroleofAPRILasautocrinegrowthfactorformegakaryocytopoiesis:D.Bonci,etal.;Blood104,3169(2004)
- LymphomaBcellsevadeapoptosisthroughtheTNFfamilymembersBAFF/BLySandAPRIL:B.He,etal.;J.Immunol.172,3268(2004)
- BAFFregulatesBcellsurvivalbydownregulatingtheBH3-onlyfamilymemberBimviatheERKpathway:A.Craxton,etal.;J.Exp.Med.202,1363(2005)
- APRILandBAFFpromoteincreasedviabilityofreplicatinghumanB2cellsviamechanisminvolvingcyclooxygenase2:P.K.Mongini,etal.;J.Immunol.176,6736(2006)
- TACIregulatesIgAproductionbyAPRILincollaborationwithHSPG:D.Sakurai,etal.;Blood109,2961(2007)
- BAFFandAPRILsupportchroniclymphocyticleukemiaB-cellsurvivalthroughactivationofthecanonicalNF-kappaBpathway:T.Endo,etal.;Blood109,703(2007)
- STAT-3ActivationbyDifferentialCytokinesIsCriticalforHumanInVivo-GeneratedPlasmaCellSurvivalandIgSecretion:B.Rodriguez-Bayona,etal.;J.Immunol.191,4996(2013)
- TheimmunoregulatorsolubleTACIisreleasedbyADAM10andreflectsBcellactivationinautoimmunity:F.S.Hoffmann,etal.;J.Immunol.194,542(2015)
- MyelopoiesisdysregulationassociatedtosustainedAPRILproductioninmultiplemyeloma-infiltratedbonemarrow:T.Matthes,etal.;Leukemia29,1901(2015)
- TNFsuperfamilymemberAPRILenhancesmidbraindopaminergicaxongrowthandcontributestothenigrostriatalprojectioninvivo:T.G.McWilliams,etal.;Exp.Neurol.298,97(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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