脂肪原/血管生成素（UIM结构域）肽（rec.）（琼脂糖）/AG-40T-0220-R500/500µl
商品编号：
AG-40T-0220-R500
品牌：
Adipogen Inc
市场价：
¥8940.00
美元价：
5364.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | S5a;26SProteasomeRegulatorySubunitS5a;ASF;Macropain;Mcb1;PSMD4;pUB-R5;Rpn10;26SProteasomeNon-ATPaseRegulatorySubunit4 |
| ProductType | Protein |
| Properties | |
| Source/Host | Synthetic |
| Sequence | Humanangiocidin(UIMdomainsaa211-301)(AccessionNr.P55036)isconjugatedtoagarose. |
| Crossreactivity | Multi-species |
| Label/Conjugates | Agarose |
| Formulation | Liquid.In50mMHEPES,pH7.5,500mMNaCl. |
| OtherProductData | Use:Thisaffinityresincanbeusedfortheenrichment,isolationandidentificationofubiquitinatedproteins,proteinsthatcontainubiquitin-likedomainsand/or26Ssubstrates.Equilibrateresinbywashingwith5-10mldesiredstartbuffer.Bindingandelutionofmaterialisdependentonindividualexperimentalconditions. Storage:Theagarosecanbere-usedforatleast2applicationsifproperlymaintained.Afteruse,cleanresinwith5ml50mMTrispH9.0,1MKCl.Removecleaningsolutionbywashingresinwith5mlstoragebuffer. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Donotfreeze. |
| Use/StABIlity | Stableforatleast3monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Angiocidin,alsoknownasS5aoranti-secretoryfactor(ASF),isclassifiedunderthegenePSMD4,butisoftenreferredtobyadifferentnamedependingonthecontextinwhichitisdescribed.S5aandASFhaveidentical377aminoacid(aa)sequences,whileangiocidinisdescribedashavinganadditionalGly255Glu256Arg257sequenceinitsC-Terminus.Thehumanproteinshares96%and99%aasequenceidentitywithitsmouseandratorthologs,respectively.Structurally,itcontainsaN-terminalvonWillebrandFactortypeAdomainandtwoC-terminalubiquitin-interactingmotifs(UIM).Itactsasaubiquitin-bindingproteinwhereitismostcommonlyreferredtoasS5aorinyeastasRpn10.Itispartofthe19Sregulatorysubunitofthe26SProteasomewhereitsUIMrecognizespoly-ubiquitinatedproteinsdestinedfordegradation.Asapartoftheproteasomecomplex,itmayalsorecognizetheubiquitin-likemodifierFAT10.FreecytoplasmicformsalsoexistwhereitsubiquitinationiscatalyzedbyarangeofubiquitinE3ligasesfromdifferentclasses.Therefore,experimentallyAngiocidinmayactasausefulsubstratetomonitortheactivityof(E3)ligases,independentoftheirspecificmechanismsofaction.IncancerBIOLOGy,whereitisoftenreferredtoasangiocidin,itisshowntoslowtumorprogression.Itisfoundintheextracellularmatrixofcertaintumorsubtypes,anditmayactbysuppressingangiogenesisorbydirectlyinhibitingtumorcellgrowth.ItalsoisfoundinseveralbiologicalfluidswhereitisknownprimarilyasASF.Itsuppressesfluidsecretioninresponsetoenterotoxinandmayactasananti-inflammatoryfactor.S5ahasalowaffinityformono-,di-andtri-ubiquitinbutbindsefficientlytotetramericubiquitinandhasapreferenceforlongerpolymers.TheproteinrecognizesubiquitinconjugatesviatwoUIM(ubiquitin-interactingmotif)domainsatlocatedatresidues211-230(I)and282-301(II).AlthoughbothUIMsbindtopoly-ubiquitininvitro,UIMIIhasa10-foldhigheraffinityforubiquitinthanUIMI.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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