当前位置：
首页
>
产品中心 >
Other_recombinant_protein >
Adipogen/Angiocidin (human) (rec.) (Biotin)/AG-40T-0217B-C250/250 µg
Adipogen/Angiocidin (human) (rec.) (Biotin)/AG-40T-0217B-C250/250 µg
商品编号：
AG-40T-0217B-C250
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 26SProteasomeRegulatorySubunitS5a;ASF;Macropain;Mcb1;PSMD4;pUB-R5;Rpn10;26SProteasomeNon-ATPaseRegulatorySubunit4;S5a |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanangiocidin(AccessionNr.P55036)conjugatedtobiotin. |
| Crossreactivity | Human |
| Label/Conjugates | Biotin |
| Formulation | Liquid.InHEPES,NaCl,DTTandGlycerol. |
| OtherProductData | Use:Idealforuseasacontrolsubstrateforinvitroubiquitinconjugation.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof1-5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
S5a/Angiocidin,alsoknownasanti-secretoryfactor(ASF),isclassifiedunderthegenePSMD4,butisoftenreferredtobyadifferentnamedependingonthecontextinwhichitisdescribed.S5aandASFhaveidentical377aminoacid(aa)sequences,whileangiocidinisdescribedashavinganadditionalGly255Glu256Arg257sequenceinitsC-Terminus.Thehumanproteinshares96%and99%aasequenceidentitywithitsmouseandratorthologs,respectively.Structurally,itcontainsaN-terminalvonWillebrandFactortypeAdomainandtwoC-terminalubiquitin-interactingmotifs(UIM).Itactsasaubiquitin-bindingproteinwhereitismostcommonlyreferredtoasS5aorinyeastasRpn10.Itispartofthe19Sregulatorysubunitofthe26SProteasomewhereitsUIMrecognizespoly-ubiquitinatedproteinsdestinedfordegradation.Asapartoftheproteasomecomplex,itmayalsorecognizetheubiquitin-likemodifierFAT10.FreecytoplasmicformsalsoexistwhereitsubiquitinationiscatalyzedbyarangeofubiquitinE3ligasesfromdifferentclasses.Therefore,experimentallyS5a/Angiocidinmayactasausefulsubstratetomonitortheactivityof(E3)ligases,independentoftheirspecificmechanismsofaction.IncancerBIOLOGy,whereitisoftenreferredtoasangiocidin,itisshowntoslowtumorprogression.Itisfoundintheextracellularmatrixofcertaintumorsubtypes,anditmayactbysuppressingangiogenesisorbydirectlyinhibitingtumorcellgrowth.ItalsoisfoundinseveralbiologicalfluidswhereitisknownprimarilyasASF.Itsuppressesfluidsecretioninresponsetoenterotoxinandmayactasananti-inflammatoryfactor.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
