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Adipogen/<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0001-C500/500 µg
Adipogen/<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0001-C500/500 µg
商品编号：
AG-40T-0001-C500
品牌：
Adipogen Inc
市场价：
¥25000.00
美元价：
15000.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TRAIL;Apo-2L;TNFSF10;CD253 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | TheextracellulardomainofhumanTRAIL(aa95-281)isfusedattheN-terminustoaHis-tagandalinkerpeptide. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseTRAILreceptorsandosteoprotegerin(OPG). |
| BIOLOGicalActivity | Potentbiologicallyactivetrimer.Inducesapoptosisinaconcentrationrangeof10-100ng/ml.Note:Doesnotrequireacross-linkingenhancerforitspotentbiologicalactivity.ED50:20ng/ml(BJABcells).Forcelllinesthatrequireextensivecross-linkingoftheTRAIL-Rsforkilling(e.g.Jurkat)useSuperKillerTRAIL™(Prod.No.AG-40T-0002). |
| Purity | ≥98%(SDS-PAGE) |
| PurityDetail | Affinitypurified.Sterilefiltered. |
| EndotoxinContent | ≤0.01EU/μgpurifiedprotein(LALtest;Lonza). |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.In20mMHEPES,pH7.4,150mMNaCl,0.005%Tween20,1%sucrose,1mMDTT. |
| OtherProductData | UniProtlinkP50591:TRAIL(human)|Note:Toretainfullactivitytheconcentrationofthealiquotsshouldbeatleast0.1mg/ml. |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. Formaximumproductrecoveryafterthawing,centrifugethevialbeforeopeningthecap. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TNF-relatedapoptosis-inducingligand(TRAIL;Apo2L;CD253;TNFSF10)isatypeIItransmembraneproteinofabout34kDa.Likemostmembersofthetumornecrosisfactor(TNF)superfamilyofcytokinesTRAILcanbecleavedatthecellsurfacebymetalloproteasestoformasolublemolecule.ActiveTRAILformstrimersandspecificallybindstofivedistinctreceptors:TRAIL-R1(DR4;Apo2;CD261;TNFRSF10A),TRAIL-R2(DR5;KILLER;TRICK2A;TRICK2B;CD262;TNFRSF10B),TRAIL-R3(DcR1;LIT;TRID;CD263;TNFRSF10C),TRAIL-R4(DcR2;TRUNDD;CD264;TNFRSF10D),andosteoprotegerin(OPG;OCIF;TNFRSF11B).TrimerizedTRAILtriggersapoptosisuponligationofcellsurfaceTRAIL-R1and/orTRAIL-R2byinducingtheformationoftheso-calledmultiproteindeath-inducingsignalingcomplex(DISC).
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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