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Adipogen/<em>Killer</em>TRAIL™ (R1 specific), Soluble (human) (rec.)/AG-40T-0003-C050/50 µg
Adipogen/<em>Killer</em>TRAIL™ (R1 specific), Soluble (human) (rec.)/AG-40T-0003-C050/50 µg
商品编号：
AG-40T-0003-C050
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TRAIL;Apo-2L;TNFSF10;CD253 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | TheextracellulardomainofhumanTRAIL(aa95-281)isfusedattheN-terminustoaHis-tagandalinkerpeptideandcontainsaasubstitutions,whichgenerateabindingspecificitytowardsTRAILreceptor1(TRAIL-R1;DR4). |
| Crossreactivity | Human |
| Specificity | BindstohumanTRAILreceptor1(DR4),butnothumanTRAIL-R2(DR5).BindingtoTRAIL-R3,-R4andosteoprotegrin(OPG)arenottested. |
| BIOLOGicalActivity | Inducesapoptosisinaconcentrationrangeof20-500ng/mlofTRAIL-R1(DR4)expressingcelllines(e.g.RAMOS).ItisinefficienttokillviaTRAIL-R2(DR5)inJurkatcells.TheactivitydependsontherelativecellularsurfaceexpressionofTRAIL-R1comparedtootherdeath-signalingTRAIL-Rs.ConcentrationsofKillerTRAIL™-R1toinduceapoptosismayvarydependingonthecelltype. Note:Thisproteindoesnotrequireacross-linkingenhancerforitspotentbiologicalactivity. |
| MW | ~26kDa |
| Purity | ≥98%(SDS-PAGE) |
| PurityDetail | Affinitypurified. |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.In20mMHEPES,pH7.9,120mMNaCl,0.01%Tween20,1%sucrose,1mMDTT. |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Oncethaweditisrecommendedtoprepareappropriatealiquotsandtostorethemat-80°C. Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TRAIL-R1isareceptorforthecytotoxicligandTRAIL.TheadaptermoleculeFADDrecruitscaspase-8totheactivatedreceptor.Theresultingdeath-inducingsignalingcomplex(DISC)performscaspase-8proteolyticactivationwhichinitiatesthesubsequentcascadeofcaspases(aspartate-specificcysteineproteases)mediatingapoptosis.PromotestheactivationofNF-κB.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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