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Adipogen/<em>Enhanced</em>FasL, Soluble (human) (rec.) Pack/AG-44B-0001-KI01/1 Set
Adipogen/<em>Enhanced</em>FasL, Soluble (human) (rec.) Pack/AG-44B-0001-KI01/1 Set
商品编号：
AG-44B-0001-KI01
品牌：
Adipogen Inc
市场价：
¥9600.00
美元价：
5760.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | APO-1L;CD95L;CD178;TNFSF6;FasLigand |
| ProductType | Set |
| Properties | |
| ApplicationSet | CompoundScreening |
| Specificity | BindstohumanandmouseFas(CD95;APO-1).InducesapoptosisofhumanJurkatTcellsataconcentrationof<0.2ng l.=""> |
| Crossreactivity | Human Mouse |
| KitContains | 1Set 1x10µgofFasL,Soluble(human)(rec.)(Prod.No.AG-40B-0001) 4x50µgofTNFLigandsEnhancer(Prod.No.AG-35B-0001) |
| OtherProductData | Source/Host: ProducedinHEK293cells.AFLAG®-tagisfusedattheN-terminusoftheextracellulardomainofhumanFasL(aa103-281). Concentration: FasL:0.1mg/mlafterreconstitution TNFLigandsEnhancer:1mg/mlafterreconstitution Purity: ≥95%(SDS-PAGE) Formulation: Lyophilized.ContainsPBS. EndotoxinContent: FasL:<0.05EU/µgpurifiedprotein(LALtest;Lonza). TNFLigandsEnhancer:<0.01EU/µgpurifiedprotein(LALtest;Lonza). Reconstitution: FasL:reconstitutewith100µlsterilewater.PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. TNFLigandsEnhancer:reconstituteeachvialwith50µlsterilewater.PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| Manual | No |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
FasL,Soluble(human)(rec.)inducesapoptosisinaconcentrationrangeof<1ng/mlinthepresenceof0.1to1µg/mlofTNFLigandsEnhancer(Prod.No.AG-35B-0001).(Optimalconditionsmustbedeterminedindividuallyforeachcelllinetested)
ProductReferences
- ActivationofFasbyFasLinducesapoptosisbyamechanismthatcannotbeblockedbyBcl-2orBcl-x(L):D.C.Huang,etal.;PNAS96,14871(1999)
- Fasligand-inducedc-JunkinaseactivationinlymphoidcellsrequiresextensivereceptoraggregationbutisindependentofDAXX,andFas-mediatedcelldeathdoesnotinvolveDAXX,RIP,orRAIDD:A.Villunger,etal.;J.Immunol.165,1337(2000)
- Fasengagementinducesthematurationofdendriticcells(DCs),thereleaseofinterleukin(IL)-1beta,andtheproductionofinterferongammaintheabsenceofIL-12duringDC-Tcellcognateinteraction:anewroleforFasligandininflammatoryresponses:M.Rescigno,etal.;J.Exp.Med.192,1661(2000)
- NF-κBsignalsinducetheexpressionofc-FLIP:O.Micheau,etal.;Mol.Cell.Biol.21,5299(2001)
- PotentiationofFas-mediatedapoptosisbyanengineeredglycosylphosphatidylinositol-linkedFas:P.Legembre,etal.;CellDeathDiffer.9,329(2002)
- MultiplepathwaysofTWEAK-inducedcelldeath:M.Nakayama,etal.;J.Immunol.168,734(2002)
- Innatedirectanticancereffectorfunctionofhumanimmaturedendriticcells.II.RoleofTNF,lymphotoxin-alpha(1)beta(2),Fasligand,andTNF-relatedapoptosis-inducingligand:G.Lu,etal.;J.Immunol.168,1831(2002)
- InductionofapoptosisinmalignantpleuralmesotheliomacellsbyactivationoftheFas(Apo-1/CD95)death-signalpathway:J.H.4thStewartetal.;J.Thorac.Cardiovasc.Surg.123,295(2002)
- Hepaticnaturalkillercellsexclusivelykillsplenic/bloodnaturalkiller-resistanttumorcellsbytheperforin/granzymepathway:D.Vermijlen,etal.;J.Leukoc.Biol.72,668(2002)
- Caspase-10isrecruitedtoandactivatedatthenativeTRAILandCD95death-inducingsignallingcomplexesinaFADD-dependentmannerbutcannotfunctionallysubstitutecaspase-8:M.R.Sprick,etal.;EMBOJ.21,4520(2002)
- AnessentialroleformembraneraftsintheinitiationofFas/CD95-triggeredcelldeathinmousethymocytes:A.O.Hueber,etal.;EMBORep.3,190(2002)
- Cuttingedge:SDS-stableFasmicroaggregates:anearlyeventofFasactivationoccurringwithagoNISTicanti-FasantibodybutnotwithFasligand:P.Legembre,etal.;J.Immunol.171,5659(2003)
- Theroleofp53andFasinamodelofacutemurinegraft-versus-hostdisease:S.Yada,etal.;J.Immunol.174,1291(2005)
- CD1d-unrestrictedhumanNKTcellsreleasechemokinesuponFasengagement:M.Giroux&F.Denis;Blood105,703(2005)
- AmplificationofCD95activationbycaspase8-inducedendosomalacidificationinrathepatocytes:R.Reinehr,etal.;J.Biol.Chem.283,2211(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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