脂肪原/20S免疫蛋白酶体（人）（未标记）/SBB-PP0004-C025/25µg
商品编号：
SBB-PP0004-C025
品牌：
Adipogen Inc
市场价：
¥4340.00
美元价：
2604.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Protein |
| Properties | |
| Source/Host | HumanPBMCs |
| Sequence | Human20SImmunoproteasome. |
| Crossreactivity | Human |
| Application | Experimentsshouldbecarriedoutat20Simmunoproteasomeconcentrationsbetween2-5nM.The20Simmunoproteasomeiscommonlyassociatedwiththe19S,PA28α/β,orthePA28γregulatorycomplexes.IfchoosingtoomitPA28duringuse,20Smustbechemicallyactivatedbyadditionof0.035%SDSinfinalassaybuffers. |
| MW | ~700kDa |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | Lotdependent. |
| Formulation | Liquid.In50mMHEPESpH7.5,100mMsodiumchloride,1mMTCEP. |
| OtherProductData | ClickhereforaTypicalLot-specificProductDatasheetfromtheOriginalManufacturer Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbySouthBayBio. |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -80°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
The20Simmunoproteasomeisstructurallysimilartoconstitutive26Sproteasome.The20Scoreofimmunoproteasomecontainstwoouterringscomposedofα-subunits,andtwointernal7-subunitcontainingringseachpossessing3specificsubunitsresponsIBLeforproteasomecatalyticactivity.Inimmunoproteasomesthesesubunits(ß1,ß2,ß5)arereplacedbythreeinduciblesubunits:PSMB9,PSMB10andPSMB8,(ß1i,ß2i,ß5i).Thesestress-inducedsubunitsallowfortheproductionofMHC-1associatingpeptides,whicharedisplayedasantigensonthecellsurface.ThesedisplayedpeptidescanthenberecognizedbyimmunesurveillanceCD8Tcells.20Simmunoproteasomeisrecognizedasastrongdrugtargetforautoimmunediseaseandcancer.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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