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Adipogen/Progranulin (human) ELISA Kit/AG-45A-0018YTP-KI01/2 x 96 wells
Adipogen/Progranulin (human) ELISA Kit/AG-45A-0018YTP-KI01/2 x 96 wells
商品编号：
AG-45A-0018YTP-KI01
品牌：
Adipogen Inc
市场价：
¥18000.00
美元价：
10800.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Proepithelin;PEPI;PCCell-derivedGrowthFactor |
| ProductType | Kit |
| Properties | |
| ApplicationSet | QuantitativeELISA |
| Specificity | Detectshumanprogranulin. |
| Crossreactivity | Human |
| Quantity | 1x96wells 2x96wells(TwinPlex) |
| Sensitivity | 32pg/ml |
| Range | 0.063to4ng/ml |
| SampleType | CellCultureSupernatant Plasma Serum Urine |
| AssayType | Sandwich |
| DetectionType | Colorimetric |
| OtherProductData | NOTE:TheTwinPlexsizeissuppliedas2independentSinglePlateKitsfromthesamelot. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Afterstandardreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. Plateandreagentsshouldreachroomtemperaturebeforeuse. |
| Use/StABIlity | 12monthsafterthedayofmanufacturing.SeeexpirydateonELISAKitbox. |
| Documents | |
| Manual |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Progranulin(PGRN)isawidelyexpressedpluripotentgrowthfactorwhichplaysaroleinprocessessuchasdevelopment,woundrepairandinflammationbyactivatingsignalingcascadesthatcontrolcellcycleprogressionandcellmotility.Itsfunctioninthecentralnervoussystemisofinterest,asmutationsinthePGRNgenewerefoundincasesoffrontotemporaldegeneration(FTLD).Inaddition,PGRNhasalsobeenlinkedtotumOrigenesis.Newcutting-edgepublicationshaveshownthatprogranulinmightbeabioMarkernotonlyforFTLD,butalsoforothertypesofAlzheimer‘sdisease(AD).ThisnewdataevensupposesthepotentialofprogranulintobeabiomarkerforMCI(MildCognitiveImpairment),whichwouldbeahallmarkinADresearch.Additionally,PGRNisdescribedasanewligandofTNFreceptorsandapotentialtherapeuticagainstinflammatorydiseaselikearthritis.
ProductReferences
- Lowplasmaprogranulinlevelspredictprogranulinmutationsinfrontotemporallobardegeneration:R.Ghidoni,etal.;Neurology71,1235(2008)
- CommonvariationinthemiR-659binding-siteofGRNisamajorriskfactorforTDP43-positivefrontotemporaldementia:R.Rademakers,etal.;Hum.Mol.Genet.17,3631(2008)
- SerumprogranulinconcentrationsmaybeassociatedwithmacrophageInfiltrationintoomentalADIposetissue:B.S.Youn,etal.;Diabetes58,627(2009)
- Plasmaprogranulinlevelspredictprogranulinmutationstatusinfrontotemporaldementiapatientsandasymptomaticfamilymembers:N.Finch,etal.;Brain132,583(2009)
- ProgranulinplasmalevelsaspotentialbiomarkerfortheidentificationofGRNdeletioncarriers.AcasewithatypicalonsetasclinicalamnesticMildCognitiveImpairmentconvertedtoAlzheimer"sdisease:M.Carecchio,etal.;J.Neurol.Sci.287,291(2009)
- Cerebrospinalfluidprogranulinlevelsinpatientswithdifferentmultiplesclerosissubtypes:M.DeRiz,etal.;Neurosci.Lett.469,234(2010)
- LowSerumProgranulinPredictsthePresenceofMutations:AProspectiveStudy:E.C.Schofield,etal.;J.AlzheimersDis.22,981(2010)
- ANovelProgranulinMutationCausingFrontotemporalLobarDegenerationwithHeterogeneousPhenotypicExpression:G.Rossi,etal.;J.AlzheimersDis.23,7(2010)
- Pathogeniccysteinemutationsaffectprogranulinfunctionandproductionofmaturegranulins:J.Wang,etal.;J.NeuRochem.112,1305(2010)
- Microglialupregulationofprogranulinasamarkerofmotorneurondegeneration:T.Philips,etal.;J.Neuropathol.Exp.Neurol.69,1191(2010)
- Anovelprogranulinmutationcausingfrontotemporallobardegenerationwithheterogeneousphenotypicexpression:G.Rossi,etal.;J.AlzheimersDis.23,7(2011)
- rs5848polymorphismandserumprogranulinlevel:G.Y.Hsiung,etal.;J.Neurol.Sci.300,28(2011)
- AssociationofTMEM106BGenePolymorphismWithAgeatOnsetinGranulinMutationCarriersandPlasmaGranulinProteinLevels:C.Cruchaga,etal.;Arch.Neurol.68,5812011
- Progranulinexpressioninbraintissueandcerebrospinalfluidlevelsinmultiplesclerosis:M.Vercellino,etal.;Mult.Scler.17,1194(2011)
- SolubleBeta-amyloidprecursorproteinisrelatedtodiseaseprogressioninamyotrophiclateralsclerosis:Steinacker,etal.;PLoSOne.6,e23600(2011)
- Lossoffunctionmutationsintheprogranulingenearerelatedtopro-inflammatorycytokinedysregulationinfrontotemporallobardegenerationpatients:P.Bossù,etal.;J.Neuroinflammation8,65(2011)
- MucosalProgranulinexpressionisinducedbyH.pylori,butindependentofSecretoryLeukocyteProteaseInhibitor(SLPI)expression:T.Wex,etal.;BMCGastroenterol.11,63(2011)
- PhenotypicheterogeneityoftheGRNAsp22fsmutationinalargeItaliankindred:A.M.Pietroboni,etal.;J.AlzheimersDis. 24,253(2011)
- ProgranulinGeneticScreeninginFrontotemporalLobarDegenerationPatientsFromCentralItaly:S.Bagnoli,etal.;CellMol.Neurobiol.32,13(2011)
- OptimalPlasmaProgranulinCutoffValueforPredictingNullProgranulinMutationsinNeurodegenerativeDiseases:AMulticenterItalianStudy:R.Ghidoni,etal.;Neurodegener.Dis.9,121(2012)
- Prevalenceoffrontotemporallobardegenerationinanisolatedpopulation:theVallecamonicastudy:N.Gilberti,etal.;Neurol.Sci.33,899(2012)
- GranulinmutationdrivesbraindamageandreorganizationfrompreclinicaltosymptomaticFTLD:B.Borroni,etal.;Neurobiol.Aging.33,2506(2012)
- MiningtheGastricCancerSecretome:IdentificationofGRNasaPotentialDiagnosticMarkerforEarlyGastricCancer:H.Loei,etal.;J.ProteomeRes.11,1759(2012)
- Twopatternsofadipokineandotherbiomarkerdynamicsinalong-termweightlossintervention:M.Blueher,etal.;DiabetesCare35,342(2012)
- ExpansionmutationinC9ORF72doesnotinfluenceplasmaprogranulinlevelsinfrontotemporaldementia:O.Dols-Icardo,etal.;Neurobiol.Aging33,1851(2012)
- StrikinglyDifferentClinicopathologicalPhenotypesDeterminedbyProgranulin-MutationDosage:K.R.Smith,etal.;Am.J.Hum.Genet.90,1102(2012)
- C9ORF72repeatexpansionsandotherFTDgenemutationsinaclinicalADpatientseriesfromMayoClinic:A.Wojtas,etal.;Am.J.Neurodegener.Dis.1,107(2012)
- ProgranulinasaPrognosticBiomarkerforBreastCancerRecurrenceinPatientsWhoHadHormoneReceptor-PositiveTumors:ACohortStudy: D.H.Koo,etal.;PLoSOne7, e39880(2012)
- Clinical,Neuropathological,andGeneticCharacteristicsoftheNovelIVS9+1delGGRNMutationinaPatientwithFrontotemporalDementia:R.Taipaa,etal.;J.AlzheimersDis. 30, 83(2012)
- EarlyOnsetBehavioralVariantFrontotemporalDementiaduetotheC9ORF72HexanucleotideRepeatExpansion:PsychiatricClinicalPresentations:A.Arighi,etal.;J.AlzheimersDis. 31, 447(2012)
- SerumProgranulinLevelsinPatientswithFrontotemporalLobarDegenerationandAlzheimer"sDisease:DetectionofGRNMutationsinaSpanishCohort:A.Antonell,etal.;J.AlzheimersDis.31,581(2012)
- Progranulinasaprognosticbiomarkerforbreastcancerrecurrenceinpatientswhohadhormonereceptor-positivetumors:acohortstudy:D.H.Koo,etal.;PLoSOne7,e39880(2012)
- CirculatingProgranulinLevelsinWomenwithGestationalDiabetesMellitusandHealthyControlsDuringandAfterPregnancy:J.Todoric,etal.;Eur.J.Endocrinol.167,561(2012)
- Epidemiologyandgeneticsoffrontotemporaldementia:adoor-to-doorsurveyinSouthernItaly:L.Bernardi,etal.;Neurobiol.Aging33,2948(2012)
- TMEM106B,theriskgeneforfrontotemporaldementia,isregulatedbythemicroRNA-132/212clusterandaffectsprogranulinpathways:A.S.Chen-Plotkin,etal.;J.Neurosci.32,11213(2012)
- Alterationincellcycle-relatedproteinsinlymphoblastsfromcarriersofthec.709-1G>APGRNmutationassociatedwithFTLD-TDPdementia:C.Alquezara,etal.;Neurobiol.Aging33,429.e7(2012)
- Pooled-DNAsequencingidentifiesnovelcausativevariantsinPSEN1,GRNandMAPTinaclinicalearly-onsetandfamilialAlzheimer"sdiseaseIbero-Americancohort:S.C.Jin,etal.;AlzheimersRes.Ther.4,34(2012)
- StructuralBrainSignatureofFTLDDrivenbyGranulinMutation:M.Bozzali,etal.;J.AlzheimersDis.33,483(2012)
- Progranulinantibodiesinautoimmunediseases:L.Thurner,etal.;J.Autoimmun.42,29(2013)
- Progranulingene(GRN)promotermethylationisincreasedinpatientswithsporadicfrontotemporallobardegeneration:D.Galimberti,etal.;Neurol.Sci.34,899(2013)
- GRNVariantrs5848ReducesPlasmaandBrainLevelsofGranulininAlzheimer"sDiseasePatients:A.Kamalainen,etal.;J.AlzheimersDis.33,23(2013)
- ImplicationofProgranulinandC1q/TNF-RelatedProtein-3(Ctrp3)onInflammationandAtherosclerosisinSubjectswithorwithoutMetabolicSyndrome:H.J.Yoo,etal.;PLOSOne8,e55744(2013)
- Screeningforprogranulinmutationsbyserumproteindosageincommonneurodegenerativedisorders:E.Rodriguez-Rodriguez,etal.;Parkinson.Rel.Disord.19,768(2013)
- Novelprogranulinmutationswithreducedserum-progranulinlevelsinfrontotemporallobardegeneration:H.-H.Chiang,etal.;Eur.J.Hum.Gen.21,1260(2013)
- Progranulinantibodiesentertainaproinflammatoryenvironmentinasubgroupofpatientswithpsoriaticarthritis:L.Thurner,etal.;ArthritisRes.Ther.15,R211(2013)
- Crosstalkbetweencirculatingperoxisomeproliferator-activatedreceptorgamma,adipokinesandmetabolicsyndromeinobesesubjects:K.Mirzaei,etal.;Diabetol.Metabol.Syndr.5,79(2013)
- ImplicationsofC1q/TNF-relatedprotein-3(CTRP-3)andprogranulininpatientswithacutecoronarysyndromeandstableanginapectoris:K.M.Choi,etal.;Cardiovasc.Diabetol.13,14(2014)
- Circulatingprogranulinlevelisassociatedwithvisceralfatandelevatedliverenzymes:Significanceofserumprogranulinasausefulmarkerforliverdysfunction:Y.Tanaka,etal.;Endocr.J.61,1191(2014)
- Identificationofadipokineclustersrelatedtoparametersoffatmass,insulinsensitivityandinflammation:G.Flehmig,etal.;PLoSOne9,e99785(2014)
- ProgranulinIsAssociatedwithDiseaseActivityinPatientswithRheumatoidArthritis:L.A.Cerezo,etal.;MediatorsInflamm.2015,740357(2015)
- ProgranulinasacandidatebiomarkerfortherapeutictrialinpatientswithALSandFTLD:E.FeNEBerg,etal.;J.Neural.Transm.123,289(2016)
- SerumprogranulinlevelsinHispanicrheumatoidarthritispatientstreatedwithTNFantagoNISTs:aprospective,observationalstudy:J.Johnson,etal.;Clin.Rheumatol.36,507(2016)
- ReducedmiR-659-3plevelscorrelatewithprogranulinincreaseinhypoxicconditions:implicationsforfrontotemporaldementia:P.Piscopo,etal.;Front.Mol.Neurosci.9,31(2016)
- Prosaposinisaregulatorofprogranulinlevelsandoligomerization:A.M.Nicholson,etal.;Nat.Commun.7,11992(2016)
- Missensemutationsinprogranulingeneassociatedwithfrontotemporallobardegeneration:studyofpathogeneticfeatures:C.M.Karch,etal.;Neurobiol.Aging38,215.e1(2016)
- Progranulinmutationanalysis:Identificationofonenovelmutationinexon12associatedwithfrontotemporaldementia:P.M.Aswathy,etal.;Neurobiol.Aging39,218.e1(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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