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Adipogen/IL-37 (human) ELISA Kit/AG-45A-0041YTP-KI01/2 x 96 wells
Adipogen/IL-37 (human) ELISA Kit/AG-45A-0041YTP-KI01/2 x 96 wells
商品编号：
AG-45A-0041YTP-KI01
品牌：
Adipogen Inc
市场价：
¥21000.00
美元价：
12600.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Interleukin-1FamilyMember7;IL-1F7;FIL1zeta;IL-1X;Interleukin-1Homolog4;IL-1H4;Interleukin-1zeta;IL-1zeta;IL-1RP1;IL1F7;FIL1Z,IL1H4,IL1RP1 |
| ProductType | Kit |
| Properties | |
| ApplicationSet | QuantitativeELISA |
| Specificity | DetectshumanIL-37(monomericanddimericforms).Doesnotcross-reactwithhumanIL-33,IL-38,IL-6,IL-23,IL-24ormouseIL-33andIL-38. |
| Crossreactivity | Human |
| Quantity | 1x96wells 2x96wells(TwinPlex) |
| Sensitivity | 10pg/ml |
| Range | 0.016to1ng/ml |
| SampleType | Plasma Serum |
| AssayType | Sandwich |
| DetectionType | Colorimetric |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Afterstandardreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. Plateandreagentsshouldreachroomtemperaturebeforeuse. |
| Use/StABIlity | 12monthsafterthedayofmanufacturing.SeeexpirydateonELISAKitbox. |
| Documents | |
| Manual |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IL-37(IL-1F7;IL-1H4)isanIL-1familymemberthatisexpressedonlyincertaintypesofhumanorgansandcellssuchasheart,thymus,testis,kidney,mononuclearcells(PBMCs)anddendriticcells.IL-37isaninhibitorofinnateimmunitywithanti-inflammatoryproperties.Itbindstotheinterleukin-18receptor(IL-18R)anditsco-receptorSIGIRR.IL-37issecretedasafull-lengthandasaprocessedformstartingfromaminoacidVal46.Itplaysanimportantroleasalinkbetweeninnateandadaptiveimmunityandactsasaninhibitorofautoimmunediseasesandtumorgrowth.IL-37alsoinhibitedLipopolysaccharide(LPS)-inducedimmunologicalreactionandLPS-inducedosteoclastformationandboneresorption.ArecentstudyindicatesthatIL-37proteinformsahead-to-headhomodimerandthisstructurelimitsitsbioactivity.Variantswithmutationsconvertingthecytokineintoamonomericformare13foldmoreactivethanthedimericIL-37.
ProductReferences
- SerumInterleukin-37ConcentrationsandHBeAgSEROconversioninChronicHBVPatientsDuringTelbivudineTreatment:C.Li,etal.;J.InterferonCytokineRes.33,612(2013)
- Elevatedlevelsofcerebrospinalfluidandplasmainterleukin-37inpatientswithguillain-barrésyndrome:C.Li,etal.;MediatorsInflamm.2013,639712(2013)
- IL-37inhibitstheproductionofinflammatorycytokinesinperipheralbloodmononuclearcellsofpatientswithsystemiclupuserythematosus:itscorrelationwithdiseaseactivity:L.Ye,etal.;J.Transl.Med.12,69(2014)
- PlasmaLevelsofIL-37andCorrelationwithTNF-α,IL-17A,andDiseaseActivityduringDMARDTreatmentofRheumatoidArthritis:P.-W.Zhao,etal.;PLOSOne9,e95346(2014)
- Evaluatingthelevelsofinterleukin-1familycytokinesinsporADIcamyotrophiclateralsclerosis:P.Italiani,etal.;J.Neuroinflamm.11,94(2014)
- ElevatedplasmaIL-37,IL-18,andIL-18BPconcentrationsinpatientswithacutecoronarysyndrome:Q.Ji,etal.;Mediat.Inflamm.2014,ID165742(2014)
- Interleukin-37isincreasedinankylosingspondylitispatientsandassociatedwithdiseaseactivity:B.Chen,etal.;J.Transl.Med.13,36(2015)
- Interleukin-37suppressestumorgrowththroughinhibitionofangiogenesisinnon-smallcelllungcancer:G.Ge,etal.;J.Exp.Clin.CancerRes.35,13(2016)
- ClinicalassociationsofIL-10andIL-37insystemiclupuserythematosus:J.Godsell,etal.;Sci.Reports 6,34604(2016)
- Elevatedseruminterleukin-37levelisapredictivebioMarkerofpoorprognosisinepithelialovariancancerpatients:J.Huo,etal.;Arch.Gynecol.Obstet.295, 459(2017)
- Interleukin-37elevationinpatientswithatrialfibrillation:W.Li,etal.;Clin.Cardiol.40,66(2017)
- Homodimerizationattenuatestheanti-inflammatoryactivityofinterleukin-37:A.M.Ellisdon,etal.;Sci.Immunol.2,eaaj1548(2017)
- ElevatedIL-37levelsintheplasmaofpatientswithseverecoronaryarterycalcification:M.Chai,etal.;J.Geriatr.Cardiol.14,285(2017)
- IL-37increasedinpatientswithacutecoronarysyndromeandassociatedwithaworseclinicaloutcomeafterST-segmentelevationacutemyocardialinfarction:K.Liu,etal.;Clin.Chim.Acta468,140(2017)
- PlasmaIL-37ElevatedinPatientswithChronicHeartFailureandPredictedMajorAdverseCardiacEvents:A1-YearFollow-UpStudy:X.Shou,etal.;Dis.Markers9134079(2017)
- MeasurementofElevatedIL-37LevelsinAcuteIschemicBrainInjury:ACross-sectionalPilotStudy.A.Zafar,etal.Cureus9,e1767(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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